Thyroid function disrupting effects of fetal exposure to POPs on ADHD symptoms in children
Description: We investigated the associations between prenatal exposure to perfluoroalkyl substances(PFASs) and the thyroid hormones(THs) and thyroid antibodies(TAs) in maternal and cord blood while considering maternal TAs status. Maternal PFASs were differently associated with THs and TAs of children between in maternal TA-negative group and TAs-positive group, and between boys and girls. Additionally, we investigated the impact of maternal PFAS exposure on children’s attention deficit hyperactive disorder(ADHD) symptoms at 8 years with the mediating effect of TH and TA. Significant inverse associations were found between some PFASs in maternal serum and ADHD symptoms among firstborn children. Assuming causality, we found only one significance: the maternal FT4 mediated 16.3% of the estimated effect of PFUnDA exposure on hyperactivity-impulsivity among firstborn children.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Sachiko Itoh
Institution: Hokkaido University
Funded outputs count: 5
Funder award ID: 18K10042
OpenAlex ID: G613678854