Endogenous Regulators of Inflammation in Periodontal Tissue Homeostasis
Description: Current proposal will characterize the role of ubiquitination with specific focus being on the function and regulation of A20 in host-oral microbiome interactions as they relate to the key cellular and molecular pathways in the course of PD. Studying the relationship between A20, oral microbiome and miRNAs will unveil novel biological and mechanistic insights and lead to new concepts and therapeutics not only for PD but also for other local infection driven inflammatory conditions as well as diseases associated with PD such as oral cavity malignancies and aging related conditions.
Funding type: research
Funder scheme: R01
Start date: 2018-06-12
End date: 2025-05-31
Investigator: SINEM ESRA SAHINGUR
Institution: UNIVERSITY OF PENNSYLVANIA
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Funded outputs count: 10
Funder award ID: R01DE027374
OpenAlex ID: G7157459192