Get started
Award

Causal epigenetic changes during aging and caloric restriction

Amount: €352,800
Funding type: grant
Start date: 2016-06-01
Funded outputs count: 69
Funder award ID: P29203
OpenAlex ID: G6186480481
Polyamine-mediated inhibition of ferroptosis contributes to geroprotection
2026 · Frank Madeo, Didac Carmona-Gutierrez, et al. · Cell Stress · 1
PDF
Do metabolic fluxes change with age?
2026 · Sebastian J. Hofer, Anna Katharina Simon, et al. · Trends in Endocrinology and Metabolism
Effects of Spermidine Supplementation on Vascular Brain Health in Older Individuals with Subjective Cognitive Decline - An Exploratory MRI Analysis
2026 · Claudia Schwarz, Katharina Wurdack, et al. · Aging and Disease
PDF
The geroprotective potential of chalcones
2025 · Didac Carmona-Gutierrez, Andreas Zimmermann, et al. · Nature Communications · 3
PDF
Spermidine alleviates depression via control of the stress response
2024 · Sarah Mackert, Christine Niemeyer, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
PDF
Sex- and timing-specific effects of fasting and caloric restriction
2023 · Sebastian J. Hofer, Frank Madeo · Cell Metabolism · 7
Molecular targets of spermidine: implications for cancer suppression
2023 · Andreas Zimmermann, Sebastian J. Hofer, et al. · Cell Stress · 22
PDF
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
2023 · Luis Filipe Costa-Machado, Esther Garcia-Dominguez, et al. · Nature Communications · 44
PDF
Antagonistic pleiotropy: the example of cardiac insulin-like growth factor signaling, which is essential in youth but detrimental in age
2023 · Mahmoud Abdellatif, Frank Madeo, et al. · Expert Opinion on Therapeutic Targets · 7
PDF
Glucose Metabolism and Metabolomic Changes in Response to Prolonged Fasting in Individuals with Obesity, Type 2 Diabetes and Non-Obese People—A Cohort Trial
2023 · Norbert J. Tripolt, Sebastian J. Hofer, et al. · Nutrients · 14
PDF
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease
2022 · Léa Montégut, Adrien Joseph, et al. · Autophagy · 26
High plasma concentrations of acyl‐coenzyme A binding protein ( ACBP ) predispose to cardiovascular disease: Evidence for a phylogenetically conserved proaging function of ACBP
2022 · Léa Montégut, Adrien Joseph, et al. · Aging Cell · 46
PDF
The rise of Candida auris: from unique traits to co-infection potential
2022 · Nadine B. Egger, Katharina Kainz, et al. · Microbial Cell · 47
PDF
IGF1 Receptor Inhibition Amplifies the Effects of Cancer Drugs by Autophagy and Immune-Dependent Mechanisms
2022 · Tian, Ailing · HAL
PDF
A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer’s disease
2022 · Jelena Tadic, Julia Ring, et al. · Cell Stress · 9
PDF
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
2022 · Julia Ring, Jelena Tadic, et al. · EMBO Molecular Medicine · 28
The effect of spermidine on autoimmunity and beta cell function in NOD mice
2022 · Ceren Karacay, Barbara Prietl, et al. · Scientific Reports · 21
PDF
Murals meet microbes: at the crossroads of microbiology and cultural heritage
2021 · Maria A. Bauer, Katharina Kainz, et al. · Microbial Cell · 4
PDF
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
2021 · Sebastian J Hofer, Didac Carmona‐Gutierrez, et al. · EMBO Molecular Medicine · 210
Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients
2021 · Mélanie Bourgin, Lisa Derosa, et al. · Aging · 14
PDF
Caloric Restriction Mimetics in Nutrition and Clinical Trials
2021 · Sebastian J. Hofer, Sergio Davinelli, et al. · Frontiers in Nutrition · 109
PDF
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
2021 · Sebastian J. Hofer, YongTian Liang, et al. · Autophagy · 93
PDF
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction
2021 · YongTian Liang, Chengji Piao, et al. · Cell Reports · 131
PDF
Dietary spermidine improves cognitive function
2021 · Sabrina Schroeder, Sebastian J. Hofer, et al. · Cell Reports · 225
PDF
Spermidine supplementation in rare translation associated disorders
2021 · Andreas Zimmermann, Didac Carmona-Gutierrez, et al. · Cell Stress · 5
PDF
Year
Topic