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The Role of Fibroblast-derived Osteopontin in Tumorigenesis

Description: Relevance Statement Age is the largest risk factor for the development of cancer. Therefore, understanding the age related changes that impact cancer development will increase our understanding of the process and supply us with better medical interventions. This project proposes to study how changes in the normal cells that surround a tumor (referred to as stromal cells) influence tumor development. To this end, we will study a molecule (osteopontin) elevated in aged, tumor promoting cells and determine how it promotes the development of cancer.
Funding type: research
Funder scheme: R01
Start date: 2009-06-17
End date: 2015-04-30
Investigator: SHEILA A STEWART
Institution: WASHINGTON UNIVERSITY
Subfield: Rheumatology
Field: Medicine
Funded outputs count: 14
Funder award ID: R01CA130919
OpenAlex ID: G3612959415
Faculty Opinions recommendation of A framework for advancing our understanding of cancer-associated fibroblasts.
2020 · Paul Timpson · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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A framework for advancing our understanding of cancer-associated fibroblasts
2020 · Erik Sahai, Igor Astsaturov, et al. · Nature reviews. Cancer · 3,863
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Therapy-Induced Senescence Drives Bone Loss
2020 · Zhangting Yao, Bhavna Murali, et al. · Cancer Research · 129
The p38MAPK-MK2-HSP27 Pathway Regulates the mRNA Stability of the Senescence-Associated Secretory Phenotype
2019 · Hayley R. Moore, Elise Alspach, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss
2018 · Bhavna Murali, Qihao Ren, et al. · Cancer Research · 67
c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors
2017 · Kevin C. Flanagan, Elise Alspach, et al. · Oncotarget · 26
Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork
2017 · Shankar Parajuli, Daniel C. Teasley, et al. · Journal of Biological Chemistry · 71
Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype
2017 · Flanagan, Kevin · Open Scholarship Institutional Repository (Washington University in St. Louis)
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DNA Replication Challenges: Telomeres and R loops
2017 · Parajuli, Shankar · Open Scholarship Institutional Repository (Washington University in St. Louis)
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RNA-binding Protein Immunoprecipitation (RIP) to Examine AUF1 Binding to Senescence-Associated Secretory Phenotype (SASP) Factor mRNA
2015 · Elise Alspach, Sheila Stewart · BIO-PROTOCOL · 27
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
2014 · Elise Alspach, Kevin C. Flanagan, et al. · Cancer Discovery · 167
Senescence and the Pro-tumorigenic Stroma
2013 · Elise Alspach, Yujie Fu, et al. · Critical Reviews™ in Oncogenesis · 47
Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
2012 · Ermira Pazolli, Elise Alspach, et al. · Cancer Research · 192
Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway
2011 · Xianmin Luo, Megan K. Ruhland, et al. · Molecular Cancer Research · 59
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