Topical Senolytics for Chronic Wound Healing
Description: PROJECT NARRATIVE In the United States, chronic wounds affect millions of people annually, predominantly the elderly. This proposal focuses on the impact of cellular aging (senescence) on age-related skin dysfunction, resulting in elevated risk for non-healing wounds. To effectively treat and prevent delayed wound healing, we developed the first clinical-grade topical senolytic drugs (i.e., agents that selectively eliminate senescent cells), for chronic wounds such as diabetic foot ulcers.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R03
Start date: 2023-08-15
End date: 2025-08-14
Investigator: SARANYA PURUSHOTHAMAN WYLES (lead)
Institutions: Mayo Clinic, MAYO CLINIC ROCHESTER
Topic: Wound Healing and Treatments
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Funded outputs count: 9
Funder award ID: R03AG082919
OpenAlex ID: G4286680244