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Mitochondria in the Regulation of Terminal Erythropoiesis

Description: PROJECT NARRATIVE Studies proposed here are designed to elucidate mitochondrial-mediated mechanisms that contribute to red blood cell (RBC) production, are specifically involved in last stages of precursor maturation and may be altered in erythroid disorders. Specifically, the findings from this application are aimed at identifying new components of the RBC production path to devise effective organelle- based therapies for erythroid disorders and efficacious approaches for improving RBC generation.
Funding type: research
Funder scheme: R01
Start date: 2017-01-01
End date: 2026-11-30
Investigator: SAGHI GHAFFARI
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Funded outputs count: 21
Funder award ID: R01HL136255
OpenAlex ID: G9000887330
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
2025 · Tasleem Arif, Jiajing Qiu, et al. · Cell stem cell · 22
Mitochondrial regulation of erythropoiesis in homeostasis and disease
2024 · Vijay Menon, Mary Slavinsky, et al. · British Journal of Haematology · 19
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Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis
2023 · Attiya Kalair, Matilde Pavan, et al. · PLoS ONE · 9
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Elevated CDKN1A (P21) mediates β-thalassemia erythroid apoptosis, but its loss does not improve β-thalassemic erythropoiesis
2023 · Raymond Liang, Miao Lin, et al. · Blood Advances · 7
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Haematopoietic stem cell quiescence exposed using mitochondrial membrane potential
2022 · Saghi Ghaffari · Current Opinion in Hematology · 5
Protocol to identify and analyze mouse and human quiescent hematopoietic stem cells using flow cytometry combined with confocal imaging
2022 · Jiajing Qiu, Vijay Menon, et al. · STAR Protocols · 3
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Mitochondrial Deep Dive into Hematopoietic Stem Cell Dormancy: Not Much Glycolysis but Plenty of Sluggish Lysosomes
2022 · Jiajing Qiu, Saghi Ghaffari · Experimental Hematology · 7
Mitochondrial localization and moderated activity are key to murine erythroid enucleation
2021 · Raymond Liang, Vijay Menon, et al. · Blood Advances · 32
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Mild anemia as a single independent predictor of mortality in patients with COVID‐19
2021 · Douglas Tremblay, Joseph L. Rapp, et al. · eJHaem · 20
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Red cell distribution width is associated with mortality in non‐anemic patients with COVID‐19
2021 · Joseph L. Rapp, Douglas Tremblay, et al. · Journal of Medical Virology · 11
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Using mitochondrial activity to select for potent human hematopoietic stem cells
2021 · Jiajing Qiu, Jana Gjini, et al. · Blood Advances · 50
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Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy
2021 · Saghi Ghaffari · Cell stem cell · 26
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Erythroid enucleation: a gateway into a “bloody” world
2021 · Vijay Menon, Saghi Ghaffari · Experimental Hematology · 59
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency
2020 · Raymond Liang, Tasleem Arif, et al. · Cell stem cell · 256
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Mitochondria in the maintenance of hematopoietic stem cells: new perspectives and opportunities
2019 · Marie-Dominique Filippi, Saghi Ghaffari · Blood · 200
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Following Transcriptome to Uncover FOXO Biological Functions
2018 · Raymond Liang, Vijay Menon, et al. · Methods in molecular biology · 5
Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis
2018 · Elisabetta Beneduce, Alessandro Matte, et al. · American Journal of Hematology · 42
Transcription factors FOXO in the regulation of homeostatic hematopoiesis
2018 · Vijay Menon, Saghi Ghaffari · Current Opinion in Hematology · 38
Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm
2018 · Raymond Liang, Saghi Ghaffari · Current topics in developmental biology/Current Topics in Developmental Biology · 45
Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination
2017 · Raymond Liang, Saghi Ghaffari · Journal of Bioenergetics and Biomembranes · 28
Introduction: The First Generation of Stepchildren
2016 · Paul J. Buser
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