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DK079806

Funded outputs count: 15
Funder award ID: DK079806
OpenAlex ID: G6236678377
Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency
2015 · Erin E. Cummings, Linda P. O’Reilly, et al. · PLoS ONE · 13
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Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy
2015 · Tunda Hidvegi, Donna B. Stolz, et al. · Journal of Biological Chemistry · 35
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A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency
2014 · Linda P. O'Reilly, Olivia S. Long, et al. · Human Molecular Genetics · 43
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover
2014 · Olivia S. Long, Joshua A. Benson, et al. · Human Molecular Genetics · 46
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Isolation of serpin-interacting proteins in C. elegans using protein affinity purification
2014 · Mark T. Miedel, Xuemei Zeng, et al. · Methods · 5
Fluphenazine Reduces Proteotoxicity in C. elegans and Mammalian Models of Alpha-1-Antitrypsin Deficiency
2014 · Jie Li, Stephen C. Pak, et al. · PLoS ONE · 52
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α1-Antitrypsin deficiency and the hepatocytes – An elegans solution to drug discovery
2013 · Linda P. O’Reilly, David H. Perlmutter, et al. · The International Journal of Biochemistry & Cell Biology · 7
A Small Conductance Calcium-Activated K+ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying
2013 · Cavita K. Chotoo, Gary A. Silverman, et al. · PLoS ONE · 10
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A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans
2012 · Mark T. Miedel, Nathan J. Graf, et al. · PLoS ONE · 48
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Using Caenorhabditis elegans to Study Serpinopathies
2011 · Olivia S. Long, Sager J. Gosai, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 2
Using C. elegans to Identify the Protease Targets of Serpins In Vivo
2011 · Sangeeta R. Bhatia, Mark T. Miedel, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 8
Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z
2010 · Sager J. Gosai, Joon Hyeok Kwak, et al. · PLoS ONE · 175
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Serpins Flex Their Muscle
2010 · James C. Whisstock, Gary A. Silverman, et al. · Journal of Biological Chemistry · 112
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Serpins Flex Their Muscle
2010 · Gary A. Silverman, James C. Whisstock, et al. · Journal of Biological Chemistry · 156
Modeling Molecular and Cellular Aspects of Human Disease Using the Nematode Caenorhabditis elegans
2008 · Gary A Silverman, Cliff J Luke, et al. · Pediatric Research · 101
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