Activation of folliculogenesis by xenotransplantation with the immunodeficient animals
Description: Aiming to develop assisted reproductive technologies for the conservation of endangered animals, this study investigated a method for inducing the development of primordial follicles by transplanting ovarian tissue into immunodeficient animals using dogs and cats as models of wild carnivores. As a result of transplanting frozen canine ovarian tissue into immunocompromised rats, we demonstrated that ovarian tissue can induce follicle development from primordial to secondary follicles after 9 weeks of transplantation and that the ovarian tissue can be cryopreserved while retaining follicle development ability. To apply these results to wild animals, we are also promoting the "Ovarian Bank," which cryopreserves ovarian tissue and oocytes from wild animals. In addition, to extend the target species into birds, I have developed a cryopreservation technique to preserve oocytes in chickens, and am working on the application of this technique to endangered avian species in Japan.
Amount: ¥4,290,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2023-03-31
Investigator: Mayako Fujihara
Institution: Kyoto University
Funded outputs count: 3
Funder award ID: 17K15055
OpenAlex ID: G6251578726