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High-resolution single cell profiling of vaccine responsiveness in the elderly

Description: PROJECT NARRATIVE The vulnerability of elderly individuals to infection with influenza, even among those who have been vaccinated, is a serious public health issue. This proposal seeks to pinpoint the cell types and molecular “signatures” that distinguish those who mount protective immune responses to flu vaccine from those who do not. Such information could help researchers to design more effective vaccines in the future.

Funder: National Institute of Allergy and Infectious Diseases

Funding type: research

Funder scheme: R01

Start date: 2019-02-14

End date: 2026-01-31

Investigator: DUYGU UCAR

Institution: JACKSON LABORATORY

Funded outputs count: 40

Funder award ID: R01AI142086

OpenAlex ID: G6263602811

Post-vaccination expansion of extrafollicular Th10 and regulatory Tfr cells distinguishes strong from weak influenza vaccine responses in older adults

2026 · Avinash S. Mahajan, Sathyabaarathi Ravichandran, et al. · medRxiv

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures

2026 · Djamel Nehar-Belaid, Asa Thibodeau, et al. · Nature Communications · 8

Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination

2026 · Giray Eryilmaz, Yilmaz Yucehan Yazici, et al. · JCI Insight · 1

Dose-dependent interferon programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination

2025 · Giray Naim Eryilmaz, Yilmaz Yucehan Yazici, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and cancer

2024 · Brittany L. Angarola, Siddhartha Sharma, et al. · Nature Aging · 54

Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults

2024 · Sathyabaarathi Ravichandran, Fernando Erra-Diaz, et al. · Nature Immunology · 49

Sex Differences in Immune System Aging and Responsiveness to Vaccination

2023 · Steven Yanicke, Duygu Ucar · Public Policy & Aging Report · 12

Baseline immune states (BIS) associated with vaccine responsiveness and factors that shape the BIS

2023 · Djamel Nehar-Belaid, Mark Sokolowski, et al. · Seminars in Immunology · 21

Antibody-mediated NK cell activation as a correlate of immunity against influenza infection

2023 · Carolyn M. Boudreau, John S. Burke, et al. · Nature Communications · 30

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

2023 · Jin-Gyu Cheong, Arjun Ravishankar, et al. · Cell · 310

Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease

2023 · Daniel E. Forman, George A. Kuchel, et al. · Journal of the American College of Cardiology · 58

Group 1 and group 2 hemagglutinin stalk antibody response according to age

2023 · Laura Sánchez-de Prada, Iván Sanz-Muñoz, et al. · Frontiers in Immunology · 12

Challenges and opportunities for modeling aging and cancer

2023 · Olga Anczuków, Susie Airhart, et al. · Cancer Cell · 26

Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging

2023 · Emin Onur Karakaslar, Neerja Katiyar, et al. · Aging Cell · 97

Immunodominance hierarchy after seasonal influenza vaccination

2022 · Laura Sánchez-de Prada, Iván Sanz-Muñoz, et al. · Emerging Microbes & Infections · 15

Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons

2022 · Chris P. Verschoor, Daniel W. Belsky, et al. · Immunity & Ageing · 16

Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells

2022 · Emilie Picard, Sarah Armstrong, et al. · Immunity & Ageing · 20

Research and resource needs for understanding host immune responses to SARS-CoV-2 and COVID-19 vaccines during aging

2021 · Mercy PrabhuDas, Rebecca Fuldner, et al. · Nature Aging · 3

Granzyme B: A Double-Edged Sword in the Response to Influenza Infection in Vaccinated Older Adults

2021 · Chris P. Verschoor, Graham Pawelec, et al. · Frontiers in Aging · 13

Key Determinants of Cell-Mediated Immune Responses: A Randomized Trial of High Dose Vs. Standard Dose Split-Virus Influenza Vaccine in Older Adults

2021 · Chris P. Verschoor, Laura Haynes, et al. · Frontiers in Aging · 9

Antibody and Cell-Mediated Immune Responses Are Correlates of Protection against Influenza Infection in Vaccinated Older Adults

2021 · Chris P. Verschoor, Melissa K. Andrew, et al. · Vaccines · 21

Key policy and programmatic factors to improve influenza vaccination rates based on the experience from four high-performing countries

2020 · George Kassianos, Ashis Banerjee, et al. · Drugs in Context · 29

A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

2020 · Jamie N. Justice, Sriram Gubbi, et al. · GeroScience · 52

Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection

2020 · Raquel Muñoz-Moreno, Carles Martínez-Romero, et al. · Cold Spring Harbor Perspectives in Medicine · 31

Sestrins induce natural killer function in senescent-like CD8+ T cells

2020 · Branca I. Pereira, Roel P. H. De Maeyer, et al. · Nature Immunology · 246