Get started
Award

Cardiovascular Safety of Combination Therapies for Type 2 Diabetes Mellitus

Description: PUBLIC HEALTH RELEVANCE: The continued use of sulfonylureas after the initiation of insulin therapy is common, unsupported by evidence, and may increase the risk of adverse cardiovascular outcomes in persons with type 2 diabetes mellitus. The proposed epidemiologic cardiovascular safety studies will provide important information about these potential risks in both primary and secondary prevention populations. This work has the potential to have an immediate public health impact on the prevention of cardiovascular disease in diabetic patients.
Funding type: career_development
Funder scheme: K08
Start date: 2013-08-01
End date: 2019-07-31
Investigator: JAMES S FLOYD
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 30
Funder award ID: K08HL116640
OpenAlex ID: G3514495485
Trimethylamine N-oxide and related metabolites may regulate DNA methylation and trigger cardiovascular disease
2026 · Jiantao Ma, Chao-Qiang Lai, et al. · Clinical Epigenetics · 5
Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease
2025 · Jessica I. Lundin, Ulrike Peters, et al. · Atherosclerosis · 9
Methylome-wide association analyses of lipids and modifying effects of behavioral factors in diverse race and ethnicity participants
2025 · Yao Hu, Jeff Haessler, et al. · Clinical Epigenetics · 1
PDF
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
2024 · Brody, J.A, Sotoodehnia, N, et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
PDF
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations
2024 · Jessica I. Lundin, Ulrike Peters, et al. · Epigenetics · 10
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
2022 · M d Mesbah Uddin, Ngoc Quynh H. Nguyen, et al. · Nature Communications · 99
PDF
Integrative analysis of clinical and epigenetic biomarkers of mortality
2022 · Tianxiao Huan, Steve Nguyen, et al. · Aging Cell · 35
PDF
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
2022 · Matthias Wielscher, Pooja R. Mandaviya, et al. · Nature Communications · 138
PDF
Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease
2022 · Md Mesbah Uddin, Ngoc Quynh Nguyen, et al. · Research Square · 8
PDF
Epigenetic Age and the Risk of Incident Atrial Fibrillation
2021 · Jason D. Roberts, Eric Vittinghoff, et al. · Circulation · 121
PDF
Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
2020 · Christina A. Castellani, Ryan J. Longchamps, et al. · Genome Medicine · 119
PDF
Opioid, gabapentinoid, and nonsteroidal anti‐inflammatory medication use and the risks of atrial fibrillation and supraventricular ectopy in the Multi‐Ethnic Study of Atherosclerosis
2020 · Barbara N. Harding, Kerri L. Wiggins, et al. · Pharmacoepidemiology and Drug Safety · 5
Whole Blood DNA Methylation Signatures of Diet Are Associated With Cardiovascular Disease Risk Factors and All-Cause Mortality
2020 · Jiantao Ma, Casey M. Rebholz, et al. · Circulation Genomic and Precision Medicine · 83
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group
2019 · Marguerite R Irvin, Colleen M Sitlani, et al. · American Journal of Hypertension · 28
PDF
Epigenome-wide association analysis of daytime sleepiness in the Multi-Ethnic Study of Atherosclerosis reveals African-American-specific associations
2019 · Richard Barfield, Heming Wang, et al. · SLEEP · 41
PDF
Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals
2019 · Pooja R Mandaviya, Roby Joehanes, et al. · American Journal of Clinical Nutrition · 72
DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis
2018 · Cavin K. Ward-Caviness, Jennifer E. Huffman, et al. · Blood · 21
PDF
Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease
2017 · Zachary A. Marcum, Christopher W. Forsberg, et al. · Journal of General Internal Medicine · 32
PDF
Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group
2016 · J S Floyd, C M Sitlani, et al. · The Pharmacogenomics Journal · 18
Novel Anti-glycemic Drugs and Reduction of Cardiovascular Risk in Diabetes: Expectations Realized, Promises Unmet
2016 · James H. Flory, Jenny K. Ukena, et al. · Current Atherosclerosis Reports · 8
The Application of Genomics in Diabetes: Barriers to Discovery and Implementation
2016 · James S. Floyd, Bruce M. Psaty · Diabetes Care · 35
Use of Electronic Health Data to Estimate Heart Failure Events in a Population-Based Cohort with CKD
2016 · James S. Floyd, Robert Wellman, et al. · Clinical Journal of the American Society of Nephrology · 7
Absence of anti–HMG‐CoA reductase autoantibodies in severe self‐limited statin‐related myopathy
2016 · James S. Floyd, Jennifer A. Brody, et al. · Muscle & Nerve · 32
Validation of methods for assessing cardiovascular disease using electronic health data in a cohort of Veterans with diabetes
2015 · James S. Floyd, Marc Blondon, et al. · Pharmacoepidemiology and Drug Safety · 78
Case-control study of oral glucose-lowering drugs in combination with long-acting insulin and the risks of incident myocardial infarction and incident stroke
2015 · James S. Floyd, Kerri L. Wiggins, et al. · Pharmacoepidemiology and Drug Safety · 11
Year
Topic