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Identifying the molecular mechanisms of transgenerational epigenetic inheritance

Description: PUBLIC HEALTH RELEVANCE: Little is known about how epigenetic information inherited from parents can regulate the longevity of their descendants. In humans epidemiological data suggest that the eating habits of parents can affect diseases such as obesity in children and grandchildren. Identifying the mechanistic basis by which epigenetic information from a parent can be transmitted across generations in a model organism could define basic mechanisms of transgenerational inheritance relevant to human health.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R00

Start date: 2015-07-15

End date: 2018-06-30

Investigator: ERIC LIEBERMAN GREER

Institution: BOSTON CHILDREN'S HOSPITAL

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 15

Funder award ID: R00AG043550

OpenAlex ID: G7619348968

18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis

2023 · Noa Liberman, M. Hafiz Rothi, et al. · Molecular Cell · 25

Hypoxia induces transgenerational epigenetic inheritance of small RNAs

2022 · Simon Yuan Wang, Kathleen Kim, et al. · Cell Reports · 21

Role of epigenetics in unicellular to multicellular transition in Dictyostelium

2021 · Simon Yuan Wang, Elizabeth Ann Pollina, et al. · Genome biology · 30

N6-adenosine methylation of ribosomal RNA affects lipid oxidation and stress resistance

2020 · Noa Liberman, Zach K. O’Brown, et al. · Science Advances · 54

Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms

2019 · Noa Liberman, Simon Yuan Wang, et al. · Current Opinion in Neurobiology · 75

The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline

2019 · Simon Yuan Wang, Hui Mao, et al. · PLoS Genetics · 24

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

2019 · Konstantinos Boulias, Diana Toczydłowska-Socha, et al. · Molecular Cell · 273

Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA

2019 · Zach K. O’Brown, Konstantinos Boulias, et al. · BMC Genomics · 178

An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection

2016 · Konstantinos Boulias, Judy Lieberman, et al. · Molecular Cell · 53

N6-Methyladenine: A Conserved and Dynamic DNA Mark

2016 · Zach Klapholz O’Brown, Eric Lieberman Greer · Advances in experimental medicine and biology · 132

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

2015 · Eric Lieberman Greer, Ben Becker, et al. · Cell Research · 69

DNA N6-methyladenine: a new epigenetic mark in eukaryotes?

2015 · Guan-Zheng Luo, Mario Andres Blanco, et al. · Nature Reviews Molecular Cell Biology · 252

DNA Methylation on N6-Adenine in C. elegans

2015 · Eric Lieberman Greer, Mario Andres Blanco, et al. · Cell · 713

A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans

2014 · Eric L. Greer, Sara E. Beese-Sims, et al. · Cell Reports · 183

What’s the Mtrr with Your Grandparents?

2013 · Eric L. Greer, Yang Shi · Cell Metabolism · 1