Increased expression of PGC-1alpha in skeletal muscle suppresses the development of atherosclerosis
Description: Endurance exercise training and calorie restriction suppress the development of atherosclerosis. Considering that characteristic changes of skeletal muscle are involved in this mechanism, we focused on the transcription factors PGC-1α and FOXO-1 that cause the changes of muscles due to exercise and energy restriction. In this study, we focused on skeletal muscle-specific PGC-1α or FOXO-1 overexpression on the progression of atherosclerosis was investigated. As a result, overexpression of skeletal muscle-specific PGC-1α or FOXO-1 suppresses the progression of atherosclerosis. The physiology of bioactive substances secreted from skeletal muscle, such as β-aminoisobutyric acid and Irisin, might be involved in the suppression.
Amount: ¥17,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Shinji MIURA
Institution: University of Shizuoka
Funded outputs count: 2
Funder award ID: 18H03181
OpenAlex ID: G6290912043