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Study of Muscle, Mobility and Aging: SOMMA2

Description: SOMMA is a groundbreaking study with muscle biopsies to study mobility with aging. SOMMA2 expands the cohort to test the hypotheses that several biological pathways, such as DNA damage, play a role in the risk of disability, dementia and death; mobility disability; and change in muscle power and fitness with aging.

Funder: National Institute on Aging

Funding type: research

Funder scheme: R56

Start date: 2018-06-15

End date: 2024-09-29

Investigator: STEVEN RON CUMMINGS

Institution: CALIFORNIA PACIFIC MED CTR RES INSTITUTE

Funded outputs count: 19

Funder award ID: R56AG059416

OpenAlex ID: G277459873

Striatal dopamine and skeletal muscle energy metabolism in older adults

2026 · Caterina Rosano, Nico I Bohnen, et al. · The Journals of Gerontology Series A · 2

MicroRNA Regulatory Targets Related to VO 2 peak Decline in Older Adult Participants of the Study of Muscle, Mobility and Aging (SOMMA)

2026 · Genesio M. Karere, Fang-Chi Hsu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

MicroRNA signatures of cardiorespiratory fitness (VO2peak) in older adults: Insights from the study of muscle, mobility, and aging

2025 · Genesio M Karere, Fang-Chi Hsu, et al. · The Journals of Gerontology Series A

Rest Activity Rhythms and Their Association with Cardiorespiratory Fitness and Walking Energetics in Older Adults: Study of Muscle, Mobility, and Aging

2025 · MELISSA L. ERICKSON, TERRI L. BLACKWELL, et al. · Medicine & Science in Sports & Exercise · 2

Mito-Modulatory Medication Use and Skeletal Muscle Bioenergetics Among Older Men and Women: The Study of Muscle, Mobility, and Aging

2025 · Howard J Phang, Jaclyn Bergstrom, et al. · The Journals of Gerontology Series A · 1

Marcinek and Ferrucci response to Lanza et al.

2024 · David J. Marcinek, Luigi Ferrucci · The Journal of Physiology · 3

Muscle Mass, Strength, Power and Physical Performance and Their Association with Quality of Life in Older Adults, the Study of Muscle, Mobility and Aging (SOMMA)

2024 · Nora Petnehazy, Haley N. Barnes, et al. · The Journal of Frailty & Aging · 24

Cardiopulmonary Exercise Testing in a Prospective Multicenter Cohort of Older Adults

2024 · CODY WOLF, TERRI L. BLACKWELL, et al. · Medicine & Science in Sports & Exercise · 27

Childhood adverse life events and skeletal muscle mitochondrial function

2024 · Kate A. Duchowny, Theresa Mau, et al. · Science Advances · 15

Age Is Associated With Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility, and Aging (SOMMA)

2024 · Melissa L Erickson, Terri L Blackwell, et al. · The Journals of Gerontology Series A · 13

Associations Between D3Cr Muscle Mass and Magnetic Resonance Thigh Muscle Volume With Strength, Power, Physical Performance, Fitness, and Limitations in Older Adults in the SOMMA Study

2024 · Peggy M Cawthon, Terri L Blackwell, et al. · The Journals of Gerontology Series A · 23

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA)

2024 · Nicholas J. Day, Shane S. Kelly, et al. · Aging Cell · 31

Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA)

2024 · Zeke Zamora, Li-Yung Lui, et al. · GeroScience · 7

The Association of Skeletal Muscle Energetics With Recurrent Falls in Older Adults Within the Study of Muscle, Mobility and Aging

2024 · Philip A Kramer, Ezequiel Zamora, et al. · The Journals of Gerontology Series A · 7

The association between chrononutrition behaviors and muscle health among older adults: The study of muscle, mobility and aging

2023 · Ziling Mao, Peggy M Cawthon, et al. · Aging Cell · 19

Associations between skeletal muscle energetics and accelerometry‐based performance fatigability: Study of Muscle, Mobility and Aging

2023 · Yujia (Susanna) Qiao, Adam J. Santanasto, et al. · Aging Cell · 16

Vigor to Frailty As a Continuum—A New Approach in the Study of Muscle, Mobility, and Aging Cohort

2023 · Anne B Newman, Terri L Blackwell, et al. · The Journals of Gerontology Series A · 12

Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging

2023 · Yujia (Susanna) Qiao, Jaroslaw Harezlak, et al. · The Journals of Gerontology Series A · 8

Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age

2022 · Steven R. Cummings, Stephen B. Kritchevsky · GeroScience · 47