Ras Induced Senescence and Tumor Suppression
Description: Cellular senescence is a permanent cell cycle arrest program that has only recently been appreciated to play an important role in preventing cancer development and in limiting wound healing responses, such as fibrosis. By combining a innovative and cost- effective strategies to characterize the roles and regulation of senescence cultured cells and in mice, we will produce insights into natural processes triggered in damaged cells that limits their progression to tumors or stimulates tissue repair following damage. This knowledge will suggest ways in which to modulate senescence for therapeutic purposes.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 1999-07-01
End date: 2015-05-31
Investigator: SCOTT W. LOWE
Institution: SLOAN-KETTERING INST CAN RESEARCH
Funded outputs count: 26
Funder award ID: R01AG016379
OpenAlex ID: G4211480178