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Effect of Aging on Preadipocyte Differentiation

Funding type: research
Funder scheme: R01
Start date: 1997-05-15
End date: 2014-07-31
Investigator: JAMES L. KIRKLAND
Institution: MAYO CLINIC ROCHESTER
Funded outputs count: 102
Funder award ID: R01AG013925
OpenAlex ID: G6454321031
KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence‐Associated Secretory Phenotype
2025 · Boyi Zhang, Qilai Long, et al. · Aging Cell · 9
Cellular senescence promotes macrophage-to-myofibroblast transition in chronic ischemic renal disease
2025 · Yu Zhao, Xiang-Yang Zhu, et al. · Cell Death and Disease · 19
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Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice
2025 · Hongwei Zhang, Qixia Xu, et al. · Advanced Science · 38
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Activin A Antagonism with Follistatin Reduces Kidney Fibrosis, Injury, and Cellular Senescence-Associated Inflammation in Murine Diabetic Kidney Disease
2025 · Xiaohui Bian, Zachary K. Snow, et al. · Kidney360 · 13
Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing
2024 · Nathan S. Gasek, Pengyi Yan, et al. · Nature Aging · 43
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Multiparametric identification of putative senescent cells in skeletal muscle via mass cytometry
2024 · Yijia Li, Nameera Baig, et al. · Cytometry Part A · 3
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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
2024 · Selim Chaib, José Alberto López-Domínguez, et al. · Nature Cancer · 114
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Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics
2023 · Saranya P. Wyles, Jean D. Carruthers, et al. · Gerontology · 60
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Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
2023 · Mitzi M. Gonzales, Valentina R. Garbarino, et al. · Nature Medicine · 319
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In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
2023 · Parinya Samakkarnthai, Dominik Saul, et al. · Aging · 34
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A stress-induced cilium-to-PML-NB route drives senescence initiation
2023 · Xiaoyu Ma, Yingyi Zhang, et al. · Nature Communications · 16
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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
2023 · Joshua N. Farr, Dominik Saul, et al. · Journal of Clinical Investigation · 81
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Cellular senescence: the good, the bad and the unknown
2022 · Weijun Huang, LaTonya J. Hickson, et al. · Nature Reviews Nephrology · 1,151
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Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
2022 · Abraham S. Meijnikman, Casper C. van Olden, et al. · Diabetes · 23
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Selective kidney targeting increases the efficacy of mesenchymal stromal/stem cells for alleviation of murine stenotic‐kidney senescence and damage
2022 · Seo Rin Kim, Kai Jiang, et al. · Journal of Tissue Engineering and Regenerative Medicine · 17
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
2022 · Yi Zhu, Larissa G.P. Langhi Prata, et al. · EBioMedicine · 96
Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach
2022 · Mary C. Masters, Alan L. Landay, et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 29
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
2021 · Qixia Xu, Qiang Fu, et al. · Nature Metabolism · 341
Antidiabetic Effects of the Senolytic Agent Dasatinib
2021 · Omid Salaami, Chia-Ling Kuo, et al. · Mayo Clinic Proceedings · 26
Strategies for late phase preclinical and early clinical trials of senolytics
2021 · Erin O. Wissler Gerdes, Avanish Misra, et al. · Mechanisms of Ageing and Development · 99
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Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation
2021 · Saranya P. Wyles, Tamara Tchkonia, et al. · Plastic & Reconstructive Surgery · 42
Accelerated aging in older cancer survivors
2021 · Mina S. Sedrak, James L. Kirkland, et al. · Journal of the American Geriatrics Society · 44
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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
2021 · Utkarsh Tripathi, Rayhane Nchioua, et al. · Aging · 88
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Fisetin for COVID ‐19 in skilled nursing facilities: Senolytic trials in the COVID era
2021 · Brandon P. Verdoorn, Tamara K. Evans, et al. · Journal of the American Geriatrics Society · 50
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Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions
2021 · Utkarsh Tripathi, Avanish Misra, et al. · Mechanisms of Ageing and Development · 104
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