Inhaled Stressors and Lung Aging
Description: PROJECT NARRATIVE Air pollution and inhaled particulate matter have been recognized as major global health risks which contribute to overall disease burden and mortality. Majority of the global population lives in areas that do not meet air quality standards, therefore placing humans in elevated health risk. The impact of inhaled environmental stressors (PM2.5 and cigarette smoke) on two key component of aging, mitochondrial dysfunction and cellular senescence, remains unknown and an area of high scientific interest and impact. This work will define how PM2.5 and smoke influences mitochondrial dysfunction and senescence using translational human lung organoid and precision cut lung slice models. We will define tractable human-based models to then test tissue health-span in response to these environmental stressors to identify new therapeutic targets for lung aging.
Funder: National Institutes of Health
Amount: $667,700
Funding type: research
Funder scheme: R61
Start date: 2025-08-15
End date: 2027-07-31
Investigator: CORRINE R KLIMENT
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Funded outputs count: 2
Funder award ID: 1r61ag095927-01
OpenAlex ID: G9000909596