Development of novel therapeutics for the cochlear hearing impairments by using hiPSCs and common marmoset models
Description: We established a research platform for cochlear hearing loss using both in vitro models based on human iPS cell technology and in vivo models based on small non-human primate common marmosets, to discover new findings in embryology, cell biology and stem cell medicine. This platform has also been utilized for medical applications.We are developing and exploring methods to link the results of primate embryology to cell engineering by performing comprehensive single-cell NGS-based genetic analysis in embryonic and adult marmosets and in iPS cell-derived inner ear stem cells and inner ear cells in a cross-sectional manner.With the results, we have been further investing our 7 different methods for induction of inner ear stem/progenitor/mature cells from human ES/iPS cells.
Amount: ¥44,850,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (A)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Masato FUJIOKA
Institution: Keio University
Funded outputs count: 12
Funder award ID: 18H04065
OpenAlex ID: G6380122017