Neuron regenerative therapy by direct reprogramming of equine dermal fibroblasts
Description: In this study, equine dermal fibroblast selected by flowcytometry can be derived into neuron-pathway by specific medium and the injection of these cells into spinal cord explant resulted in the significant upregulation of neuron-related gene expression. In addition, endoscopic direct injection of these cells into the cervical spinal cord tissue in horses induced the neuron-relative gene upregulation in the host cells surrounding the injection site as well. These results demonstrated that dermal fibroblasts harvested from skin tissue can be derived into neuron by direct-reprogramming and used for spinal cord regeneration by direct injection for the treatment sites.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Akikazu Ishihara
Institution: Azabu University
Funded outputs count: 0
Funder award ID: 16K08089
OpenAlex ID: G6382425120