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Microfluids-enabled Quantitative Systems Biology Approaches to Construct Gene Networks Regulating Yeast Lifespan and Genetic Noise Dynamics During Aging

Description: Applying a quantitative network construction algorithm on replicative lifespan data collected from live yeast cells in microfluidic environments, this proposal aims to construct aging modules governing the aging and noise dynamics of single cells. Due to the conserved nature of many genetic and cell biological processes between yeast and higher eukaryotes, we expect our results will shed light on the composition of the aging network in human cells.!

Funder: National Institute of General Medical Sciences

Funding type: research

Funder scheme: R01

Start date: 2018-06-01

End date: 2022-11-30

Investigator: MURAT ACAR

Institution: YALE UNIVERSITY

Funded outputs count: 11

Funder award ID: R01GM127870

OpenAlex ID: G4602900826

Sis2 regulates yeast replicative lifespan in a dose-dependent manner

2023 · Tolga T. Ölmez, David F. Moreno, et al. · Nature Communications · 12

Phenotypic selection during laboratory evolution of yeast populations leads to a genome-wide sustainable chromatin compaction shift

2022 · David F. Moreno, Murat Acar · Frontiers in Microbiology · 1

Phenotypic plasticity as a facilitator of microbial evolution

2022 · Emerson Santiago, David F Moreno, et al. · Current Zoology · 23

Modeling aging and its impact on cellular function and organismal behavior

2021 · Emerson Santiago, David F. Moreno, et al. · Experimental Gerontology · 12

A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

2021 · Guste Urbonaite, Jimmy Tsz Hang Lee, et al. · Communications Biology · 22

Chromatin regulatory genes differentially interact in networks to facilitate distinct GAL1 activity and noise profiles

2020 · David F. Moreno, Murat Acar · Current Genetics · 1

Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast

2020 · Ping Liu, Ethan A. Sarnoski, et al. · Current Genetics · 4

Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells

2019 · Thomas Z. Young, Ping Liu, et al. · Cell Reports · 17

Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness

2019 · Ruijie Song, Murat Acar · BMC Bioinformatics · 21

Inhibition of GMP synthesis extends yeast replicative lifespan

2019 · E. A. Sarnoski, P. Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory)

The Systems Biology of Single-Cell Aging

2018 · Ruijie Song, Ethan A. Sarnoski, et al. · iScience · 30