Involvements of advanced glycation end products on the developments of peripheral arterial disease in CKD patients
Description: In the present study, we investigated the roles of AGEs in the development of vascular injury especially focusing in CKD patients with peripheral vascular disease (PAD). Serum levels of AGEs were markedly higher in CKD patients with PAD. Further, elevated AGEs levels were significantly associated with surrogate makers for atherosclerosis such as ABI and vascular calcification index in these patients. Interestingly, AGEs levels were also corelated to the incidence of sarcopenia and the severity of frail in hemodialysis patients. AGE accumulated in the gastrocnemius muscle of 5/6 nephrectomy mice in association with morphological abnormalities, capillary rarefaction, and mitochondrial dysfunction, all of which were completely inhibited by DNA-aptamer raised against AGE. Our present findings may suggest the pathological role of AGE in sarcopenia and frailty in CKD. We are now investigating the impacts of AGEs on vascular calcification using adenine-induced nephropathy model.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Ueda Seiji
Institution: Juntendo University
Subfield: Clinical Biochemistry
Domain: Life Sciences
Funded outputs count: 4
Funder award ID: 18K08251
OpenAlex ID: G6485243342