Elucidation and therapeutic intervention of the mechanism of CKD onset and aggravation due to repeated and accumulated mild renal damages
Description: The essential pathological condition of chronic kidney disease (CKD) is assumed to be due to a chronic failure of maintaining homeostasis of the body such as water / electrolyte, metabolic abnormality, anemia due to renal tubular function / interstitial region disorder. It is proposed that the onset, progression, and aggravation of CKD are caused by the accumulation of various degrees of frequent renal injury (including AKI: acute kidney injury). Researchers have traditionally focused on the Klotho protein, which is a phosphorus regulator and has physiological activities such as anti-aging and anti-fibrosis, and has hypothesized that it is greatly involved in the pathophysiology of CKD. As an experimental model, we established a model in which CKD develops and progress in mice with low expression of the klotho with frequent and minimally invasive disorders, and examined the significance of various disease exacerbating factors.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Ken Tsuchiya
Institution: Tokyo Women's Medical University
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 8
Funder award ID: 17K09714
OpenAlex ID: G6489106322