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Lonp1-mediated Degradation of Phosphorylated Tau Inside Synaptic Mitochondria and Its Contribution to Hippocampal Memory Loss During Aging

Amount: CLP 265,400
Funding type: research
Funder scheme: FONDECYT - REGULAR
Start date: 2022-01-01
End date: 2026-12-31
Investigator: CHERIL TAPIA ROJAS
Institution: UNIVERSIDAD SAN SEBASTIAN
Funded outputs count: 5
Funder award ID: 1221178
OpenAlex ID: G6509977201
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment
2026 · Claudia Jara, Leslye Venegas-Zamora, et al. · npj Aging · 5
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Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
2025 · Jesús Llanquinao-Sandoval, Karina A. Cicali, et al. · Scientific Reports · 3
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Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia
2025 · Nicole Díaz-Valdivia, Mariana Labarca, et al. · Molecular Medicine · 4
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Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3–CA1 Synapses in Mice
2024 · Jorge Parodi, Rodrigo G. Mira, et al. · Cellular and Molecular Neurobiology · 5
Contrasting Effects of an Atherogenic Diet and High-Protein/Unsaturated Fatty Acids Diet on the Accelerated Aging Mouse Model SAMP8 Phenotype
2024 · Jesús Llanquinao, Claudia Jara, et al. · Neurology International · 3
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