Award

Defining the Role of Adipogenesis in Age-Associated Adiposity

Description: Project Narrative People over age 65 typically suffer from visceral adiposity, which accelerates aging by promoting insulin resistance, cardiovascular dysfunction, and many other chronic health conditions, significantly shortening healthspan and lifespan. We will determine if age-associated adiposity is majorly contributed by the making of new fat cells, and why this ability of fat tissue is unlocked by age. Successful completion of the proposed research will provide new therapeutic avenues for the prevention and treatment of age-associated adiposity and its related chronic diseases, ultimately promoting longevity and healthy aging.
Funding type: research
Funder scheme: R56
Start date: 2019-09-01
End date: 2020-05-14
Investigator: QIONG ANNABEL WANG
Institution: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
Funded outputs count: 6
Funder award ID: R56AG063854
OpenAlex ID: G4843278882
2025 · Guan Wang, Anying Song, et al. · Nature Reviews Endocrinology · 34
2025 · Guan Wang, Gaoyan Li, et al. · Science · 44
2020 · Zhichao Wang, Tinglu Ning, et al. · EMBO Reports · 52
2020 · Wenting Dai, Guan Wang, et al. · British Journal of Cancer · 104
2019 · Anying Song, Wenting Dai, et al. · Journal of Clinical Investigation · 206
2019 · Qiong A. Wang, Philipp E. Scherer · Journal of Mammary Gland Biology and Neoplasia · 40
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