Characterization of novel signals for lifespan extension in fission yeast
Description: "How is lifespan determined?" is one of the themes that should be solved. To understand the longevity of humans and other higher animals, it is essential to understand the longevity at the cellular level. Then I attempted to elucidate the control mechanism of cellular longevity using fission yeast as a model. As a result, the following new findings were obtained. (1) Caloric restriction was the only known lifespan-extending signal, but in this study, we found sulfur depletion as a new lifespan-extending signal. (2) Sulfur depletion induced the expression of Ecl1 (extender of chronological lifespan 1) that was discovered by the applicant, and found that the lifespan extension by sulfur depletion depends on the Ecl1 family. (3) Sulfur depletion reduced ribosome expression in an Ecl1 family-dependent manner, suggesting that this is the reason for the extension of lifespan. We have accumulated important knowledge for the development of human health and longevity drug discovery.
Amount: ¥6,370,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2017-06-30
End date: 2020-03-31
Investigator: Hirofumi AIBA
Institution: Nagoya University
Funded outputs count: 12
Funder award ID: 17K19227
OpenAlex ID: G6553012423