Mechanisms of genetic variants in TH2 autoimmunity
Description: PROJECT NARRATIVE Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibrosing inflammatory disease that frequently presents with an allergic predisposition driven by a TH2 response. We have identified two genetic variants in familial IgG4-RD. Here we propose to develop immunological models how these variants cause loss of tolerance and TH2 polarization that may be relevant for non-familial IgG4-RD and other polygenic autoimmune diseases.
Funder: National Institutes of Health
Amount: $606,200
Funding type: research
Funder scheme: R01
Start date: 2024-07-05
End date: 2029-05-31
Investigator: JORG J GORONZY
Institution: MAYO CLINIC ROCHESTER
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 11
Funder award ID: 1r01ai184360-01
OpenAlex ID: G6553422226