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Glycolipid-Reactive NKT Cells, Obesity and Insulin Resistance

Description: Obesity and its associated metabolic disorders such as Type 2 diabetes constitute a serious threat to global health. The studies proposed in this grant application will investigate how subset immune cells called Natural Killer T (NKT) cells, which react to lipids and play a critical role in establishing immune and inflammatory responses, become dysfunctional and in turn influence the development of obesity and Type 2 diabetes. The results from these proposed studies will be instrumental for the development of novel preventive measures and therapies for obesity and its complications, in particular Type 2 diabetes. Page 1
Funding type: research
Funder scheme: R01
Start date: 2010-07-15
End date: 2016-06-30
Investigator: LUC VAN KAER
Institution: VANDERBILT UNIVERSITY
Subfield: Immunology
Funded outputs count: 26
Funder award ID: R01DK081536
OpenAlex ID: G3202821472
Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases
2022 · Wenqiang Song, J. Luke Postoak, et al. · Proceedings of the National Academy of Sciences · 21
Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells
2020 · Amrendra Kumar, Timothy M. Hill, et al. · Proceedings of the National Academy of Sciences · 20
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IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction
2019 · Lan Wu, Rajeev Dalal, et al. · Proceedings of the National Academy of Sciences · 114
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Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes
2018 · Luc Van Kaer, Danyvid Olivares-Villagómez · The Journal of Immunology · 101
Role of autophagy in MHC class I-restricted antigen presentation
2017 · Luc Van Kaer, Vrajesh V. Parekh, et al. · Molecular Immunology · 53
Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α + dendritic cells
2017 · Vrajesh V. Parekh, Sudheer K. Pabbisetty, et al. · Proceedings of the National Academy of Sciences · 73
Mechanisms and Consequences of Antigen Presentation by CD1
2016 · Luc Van Kaer, Lan Wu, et al. · Trends in Immunology · 42
Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation
2016 · Qiang Liu, Nader Sanai, et al. · Nature Neuroscience · 119
Innate and virtual memory T cells in man
2015 · Luc Van Kaer · European Journal of Immunology · 28
The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products
2015 · Luc Van Kaer, Vrajesh V. Parekh, et al. · Frontiers in Immunology · 75
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Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance
2014 · Lan Wu, Vrajesh V. Parekh, et al. · Proceedings of the National Academy of Sciences · 70
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CD8αα+ Innate-Type Lymphocytes in the Intestinal Epithelium Mediate Mucosal Immunity
2014 · Luc Van Kaer, Holly M. Scott Algood, et al. · Immunity · 73
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In Vitro Induction of Regulatory CD4+CD8α+ T Cells by TGF-β, IL-7 and IFN-γ
2013 · Luc Van Kaer, Whitney A. S. Rabacal, et al. · PLoS ONE · 28
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Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell–Specific Deletion of Vps34
2013 · Vrajesh V Parekh, Lan Wu, et al. · The Journal of Immunology · 165
Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells
2013 · Vrajesh V Parekh, Lan Wu, et al. · The Journal of Immunology · 71
Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance
2012 · Lan Wu, Luc Van Kaer · Adipocyte · 31
Invariant natural killer T cells as sensors and managers of inflammation
2012 · Luc Van Kaer, Vrajesh V. Parekh, et al. · Trends in Immunology · 104
Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice
2012 · Yasuhiro Andoh, Hisako Ogura, et al. · Immunobiology · 24
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
2012 · Lan Wu, Vrajesh V. Parekh, et al. · Proceedings of the National Academy of Sciences · 190
Organ-specific features of natural killer cells
2011 · Fu-Dong Shi, Hans-Gustaf Ljunggren, et al. · Nature reviews. Immunology · 414
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Natural killer T cells in health and disease
2010 · Luc Van Kaer · Frontiers in Bioscience-Scholar · 112
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NKT cell costimulation: experimental progress and therapeutic promise
2010 · Marianne J. van den Heuvel, Nitan Garg, et al. · Trends in Molecular Medicine · 63
Glatiramer acetate for treatment of MS: Regulatory B cells join the cast of players
2010 · Luc Van Kaer · Experimental Neurology · 17
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Invariant natural killer T cells: bridging innate and adaptive immunity
2010 · Luc Van Kaer, Vrajesh V. Parekh, et al. · Cell and Tissue Research · 180
Development of Spontaneous Anergy in Invariant Natural Killer T Cells in a Mouse Model of Dyslipidemia
2010 · Nicole A. Braun, Yanice V. Mendez-Fernandez, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 19
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