chronic cerebral ischemia and amyloid deposition
Description: Amyloid plaque formation is a core pathological features of Alzheimer disease. Although experimental studies have shown that global cerebral hypoperfusion leads to amyloid deposition in the hemisphere with carotid artery occlusion in rodents, the results of such occurrence are controversial in humans. In this study, we demonstrated that global cerebral hypoperfusion leading to decreased blood flow relative to metabolic demand [increased oxygen extraction fraction (OEF), misery perfusion] is associated with increases in amyloid deposition in the hemisphere with atherosclerotic major cerebral artery disease in patients. Cerebral hypoperfusion may contribute to amyloid deposition in humans. Optimal management of vascular risk factors can prevent chronic cerebral hypoperfusion, which may delay progression of Alzheimer disease.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Hiroshi Yamauchi
Institution: Research Institute, Shiga Medical Center
Funded outputs count: 6
Funder award ID: 17K09814
OpenAlex ID: G6574595705