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Effects of Glycoxidative Stress on Human Aging

Funding type: research
Funder scheme: R37
Start date: 2004-08-15
End date: 2011-06-30
Investigator: HELEN VLASSARA
Institution: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Funded outputs count: 19
Funder award ID: R37AG023188
OpenAlex ID: G2278767043
Chronic Ingestion of Advanced Glycation End Products Induces Degenerative Spinal Changes and Hypertrophy in Aging Pre-Diabetic Mice
2015 · Svenja Illien-Jünger, Young Lu, et al. · PLoS ONE · 74
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Dietary advanced glycation end products are associated with decline in memory in young elderly
2014 · Rebecca K. West, Erin Moshier, et al. · Mechanisms of Ageing and Development · 80
Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans
2014 · Weijing Cai, Jaime Uribarri, et al. · Proceedings of the National Academy of Sciences · 160
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Advanced Glycation End Products (AGE) and Diabetes: Cause, Effect, or Both?
2013 · Helen Vlassara, Jaime Uribarri · Current Diabetes Reports · 594
Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases
2013 · Jaime Uribarri, Weijing Cai, et al. · Amino Acids · 67
Increased circulating advanced glycation endproducts (AGEs) in acute trauma patients
2013 · Carl I. Schulman, Jaime Uribarri, et al. · Clinical Chemistry and Laboratory Medicine (CCLM) · 4
Managing Chronic Inflammation in the Aging Diabetic Patient With CKD by Diet or Sevelamer Carbonate: A Modern Paradigm Shift
2012 · H. Vlassara, W. Cai, et al. · The Journals of Gerontology Series A · 31
Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1
2012 · Weijing Cai, Maya Ramdas, et al. · Proceedings of the National Academy of Sciences · 326
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Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals
2011 · Michal Schnaider Beeri, Erin Moshier, et al. · Mechanisms of Ageing and Development · 145
Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
2011 · Jaime Uribarri, Weijing Cai, et al. · Diabetes Care · 320
Maternally Transmitted and Food-Derived Glycotoxins
2010 · Veronica Mericq, Cecilia Piccardo, et al. · Diabetes Care · 82
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Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet
2010 · Jaime Uribarri, Sandra Woodruff, et al. · Journal of the American Dietetic Association · 1,288
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Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging
2009 · Helen Vlassara, Massimo Torreggiani, et al. · Kidney International · 157
Protection against Loss of Innate Defenses in Adulthood by Low Advanced Glycation End Products (AGE) Intake: Role of the Antiinflammatory AGE Receptor-1
2009 · Helen Vlassara, Weijing Cai, et al. · The Journal of Clinical Endocrinology & Metabolism · 226
Advanced Glycation End Product Homeostasis
2008 · Helen Vlassara, Jaime Uribarri, et al. · Annals of the New York Academy of Sciences · 76
Aging and glycoxidant stress
2008 · Melpomeni Peppa, Jaime Uribarri, et al. · HORMONES · 82
Endothelial Dysfunction in Patients with Chronic Kidney Disease Results from Advanced Glycation End Products (AGE)-Mediated Inhibition of Endothelial Nitric Oxide Synthase through RAGE Activation
2008 · Ellena Linden, Weijing Cai, et al. · Clinical Journal of the American Society of Nephrology · 179
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation
2007 · Weijing Cai, John Cijiang He, et al. · American Journal of Physiology-Cell Physiology · 107
Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging
2007 · J. Uribarri, W. Cai, et al. · The Journals of Gerontology Series A · 570
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