Risk prediction and early detection of colorectal cancer by aberrant DNA methylation in bowel lavage fluid
Description: Molecular stool analysis is considered to be a promising approach to noninvasive colorectal cancer (CRC) screening, although it requires further improvement. Aberrant DNA methylation is a common event in CRC, and methylation of many genes is a potentially useful marker for stool-based CRC screening. We show that aberrant DNA methylation is detectable in bowel lavage fluid (BLF) obtained through oral bowel preparation. Sufficient bowel preparation enables sensitive detection of tumor-derived DNA methylation in BLF specimens. Combination with other CRC screening methods that require bowel preparation, such as sigmoidoscopy and computed tomographic colonoscopy, would be the best clinical application of the BLF methylation test.
Amount: ¥3,770,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2020-03-31
Investigator: Toshiyuki Kubo
Institution: Sapporo Medical University
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 6
Funder award ID: 18K15325
OpenAlex ID: G6649606244