Biology of lifespan and size of vertebrate using fish as a model
Description: Fish exhibit a variety of anti-aging characteristics, and are an interesting target for exploring the diversity of lifespan and aging, with some species living much longer than the maximum human lifespan and some species dying in less than a year. In this study, we proposed that the mTOR signaling, which regulates the balance between growth and aging, may be suppressed in fish during the aged stage in relation to the maintenance of lifelong muscle growth and regeneration, which is one of the anti-aging properties shown by fish. We also showed that excessive promotion of mTOR signaling promotes growth, but at the expense of various important anti-aging processes such as autophagy and DNA repair pathways, which in turn promote aging. We also revealed the possibility of post-spawning senescent cell accumulation in short-lived fish and the common genetic evolution of long-lived species in long-lived fish.
Amount: ¥17,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2017-04-01
End date: 2021-03-31
Investigator: Shigeharu Kinoshita
Institution: The University of Tokyo
Funded outputs count: 7
Funder award ID: 17H03869
OpenAlex ID: G6654768341