Study on production and functional analysis of alginate deoxysugars as new rare sugars
Description: 4-Deoxy-L-erythro-5-hexoseulose uronic acid (DEH) and 2-keto-3-deoxy-D-gluconic acid (KDG) are rare sugars produced from alginate by the action of lyase and reductase. In this study, we obtained sequence information of a novel DEH reductase gene from genomic DNA of alginate-utilizing bacteria, and developed a new method for producing KDG from DEH using the protein expression system in Escherichia coli. In addition, it was clarified that DEH has a physiological action of anti-aging effect, enhances stress tolerance and suppresses the progression of neurodegenerative diseases (polyglutamine diseases).
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Toshiyuki Shibata
Institution: Mie University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 17K00852
OpenAlex ID: G6687023259