Using proteomics technology to elucidate pathogenesis of stimulant psychosis and development of new therapy
Description: Stimulants psychosis is an extremely serious and growing problem worldwide. However, the precise mechanisms are remain unknown and the development of the pharmacotherapy is needed. In this study, Using proteomics analysis (iTRAQ), we comprehensively analyzed proteins in brains of mice treatment with stimulant.The result suggested that soluble epoxide hydrolase (sEH) is involved in the development of stimulant psychosis. Furthermore, using the sEH knockout mice and sEH inhibitor treated mice, we performed behavioral test, such as locomotion and conditioned placed preference(CPP) test. The results suggest that sEH may play a key role in pathogenesis of stimulants psychosis, and the sEH inhibitor could be potential therapeutic drug for stimulant psychosis.
Amount: ¥3,640,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2016-04-01
End date: 2018-03-31
Investigator: Qian Ren
Institution: Chiba University
Funded outputs count: 3
Funder award ID: 16K19751
OpenAlex ID: G6692219438