Get started
Award

Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center

Description: PUBLIC HEALTH RELEVANCE: The Long Life Family Study (LLFS) proposes a second examination of families enriched for exceptional longevity (EL), to discover genetic and environmental factors that contribute to healthy aging. These studies could lead to the discovery of new pathways and potential therapeutic/prevention targets affecting healthy aging and longevity.
Funding type: cooperative_agreement
Funder scheme: U01
Start date: 2004-09-30
End date: 2019-07-31
Investigator: KAARE CHRISTENSEN
Institution: DUKE UNIVERSITY
Subfield: Aging
Funded outputs count: 104
Funder award ID: U01AG023712
OpenAlex ID: G4189128803
Linguistic features from paragraph recall are markers of cognitive impairment
2026 · Seho Park, Nicole Roth, et al. · Journal of the International Neuropsychological Society
PDF
Familial healthy aging and longevity: the role of spouses
2026 · Søren Netra, Angéline Galvin, et al. · BMC Medicine
RBFOX1 association with age at onset of Alzheimer's disease
2026 · Laura Xicota, Rong Cheng, et al. · Alzheimer s & Dementia
PDF
Utility of Polygenic Risk Scores in Families with Exceptional Longevity
2025 · Laura Xicota, Rong Cheng, et al. · medRxiv · 1
PDF
Developing an accessible dementia assessment tool: Leveraging a residual network, the trail making test, and demographic data
2025 · Jingmei Yang, Samad Amini, et al. · Journal of Alzheimer s Disease · 1
Identification of novel protective loci for executive function using the trail making test part B in the Long Life Family Study
2025 · Lihua Wang, Katherine Tanner, et al. · bioRxiv (Cold Spring Harbor Laboratory)
PDF
Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA)
2025 · Eric T. Klopack, Gokul Seshadri, et al. · Aging · 4
PDF
Evidence of a novel gene locus ARHGAP44 for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study
2025 · Siyu Wang, Petra Lenzini, et al. · Physiological Genomics · 1
Epidemiology and genetic determination of measures of peripheral vascular health in the Long Life Family Study
2025 · Deidra R. Fricke, Ryan K. Cvejkus, et al. · Aging
Novel loci for triglyceride/HDL-C ratio longitudinal change among subjects without T2D
2024 · Lihua Wang, Siyu Wang, et al. · Journal of Lipid Research · 2
PDF
Novel Loci ( EIF4A2, ADIPOQ, TPRG1 ) for Triglyceride / High-density Lipoprotein Cholesterol Ratio Longitudinal Change (ΔTHR) among Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Heart Study (FHS) Offspring Cohort (OS)
2024 · Lihua Wang, Siyu Wang, et al. · medRxiv
Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study
2024 · Adam J Santanasto, Sandeep Acharya, et al. · The Journals of Gerontology Series A · 2
PDF
A Novel Gene ARHGAP44 for Longitudinal Changes in Glycated Hemoglobin (HbA1c) in Subjects without Type 2 Diabetes: Evidence from the Long Life Family Study (LLFS) and the Framingham Offspring Study (FOS)
2024 · Siyu Wang, Petra Lenzini, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS)
2024 · Ruhee Patel, Stephanie Cosentino, et al. · Brain Behavior & Immunity - Health · 1
Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer's disease
2024 · Laura Xicota, Stephanie Cosentino, et al. · Alzheimer s & Dementia · 16
PDF
The association between frailty and perceived physical and mental fatigability: The Long Life Family Study
2023 · Benjamin T. Schumacher, Dustin S. Kehler, et al. · Journal of the American Geriatrics Society · 1
PDF
Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus
2023 · Yury Loika, Elena Loiko, et al. · Aging · 5
PDF
APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages
2022 · Alexander M. Kulminski, Ethan Jain‐Washburn, et al. · Aging Cell · 16
PDF
Association of leukocyte telomere length with perceived physical fatigability
2022 · Rain Katz, Emma L. Gay, et al. · Experimental Gerontology · 11
PDF
A saturated map of common genetic variants associated with human height
2022 · Loïc Yengo, Sailaja Vedantam, et al. · Nature · 824
PDF
Low Risk for Developing Diabetes Among the Offspring of Individuals With Exceptional Longevity and Their Spouses
2022 · Iva Miljkovic, Ryan Cvejkus, et al. · Frontiers in Clinical Diabetes and Healthcare · 4
PDF
Genetic Pleiotropy Between Pulmonary Function and Age-Related Traits: The Long Life Family Study
2022 · Mary F Feitosa, Mary K Wojczynski, et al. · The Journals of Gerontology Series A · 7
PDF
Rare Genetic Variants Correlate with Better Processing Speed
2022 · Zeyuan Song, Anastasia Gurinovich, et al. · Neurobiology of Aging · 5
Digitally generated Trail Making Test data: Analysis using hidden Markov modeling
2022 · Mengtian Du, Stacy L. Andersen, et al. · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 20
Perceived Physical Fatigability Predicts All-Cause Mortality in Older Adults
2021 · Nancy W Glynn, Theresa Gmelin, et al. · The Journals of Gerontology Series A · 33
PDF
Year
Topic