Get started
Award

Elucidation of the molecular basis for age-dependent leukemogenesis towards a novel therapeutic strategy

Description: 継続課題のため、記入しない。
Amount: ¥10,400,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2024-04-01
End date: 2026-03-31
Investigator: 元美 大里
Institution: Kumamoto University
Funded outputs count: 22
Funder award ID: 23K24165
OpenAlex ID: G673036792
Telomere variant sequences encode the genetic blueprint for allele-specific telomere length
2026 · Xiaoran Chai, LaiFong Poon, et al. · Nature Communications
PDF
ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
2024 · Grishma Rane, Vivian L S Kuan, et al. · The EMBO Journal · 9
Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
2024 · Ying Zhang, Kaijing Chen, et al. · Nature Structural & Molecular Biology · 12
Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia
2024 · Akiko Niibori-Nambu, Chelsia Qiuxia Wang, et al. · Gene · 5
Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia
2024 · Kelly Ooi Kee Ong, Michelle Meng Huang Mok, et al. · Experimental Hematology · 2
Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions
2024 · Sho Kubota, Yuqi Sun, et al. · The EMBO Journal · 12
PDF
Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development
2024 · Keiko Yano-Sakamoto, Yuichiro Kitai, et al. · Biochemical and Biophysical Research Communications · 1
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
2024 · Elyse A. Olesinski, Karanpreet Singh Bhatia, et al. · Blood Cancer Discovery · 13
Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line
2024 · Sarah Momtazkari, Anahita Dev Choudhury, et al. · Journal of Leukocyte Biology · 6
IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma
2024 · Hiroki Hosoi, Shotaro Tabata, et al. · Leukemia Research Reports · 6
HEY1-NCOA2 expression modulates chondrogenic differentiation and induces mesenchymal chondrosarcoma in mice
2023 · Miwa Tanaka, Mizuki Homme, et al. · JCI Insight · 23
PDF
Childhood hematopoietic stem cells constitute the permissive window for RUNX1-ETO leukemogenesis
2023 · Mohamed Gaber Abdallah, Vania Swee Imm Teoh, et al. · International Journal of Hematology · 2
Core binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis
2023 · Mingrui Guo, Hon Man Tim Chan, et al. · Blood · 17
PDF
High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform
2023 · Cheng-Yong Tham, LaiFong Poon, et al. · Nature Communications · 70
The RUNX Family, a Novel Multifaceted Guardian of the Genome
2023 · Bibek Dutta, Motomi Osato · Cells · 11
PDF
A Myb enhancer-guided analysis of basophil and mast cell differentiation
2022 · Takayoshi Matsumura, Haruhito Totani, et al. · Nature Communications · 18
PDF
Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia
2022 · Ki Hyun Bae, Fritz Lai, et al. · Journal of Nanobiotechnology · 25
Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells
2022 · Cai Ping Koh, Avinash Govind Bahirvani, et al. · Gene · 3
PDF
Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer
2022 · Khine Myint, Linda Shyue Huey Chuang, et al. · iScience · 18
Independent origins of fetal liver haematopoietic stem and progenitor cells
2022 · Tomomasa Yokomizo, Takako Ideue, et al. · Nature · 163
Hepatic leukemia factor-expressing paraxial mesoderm cells contribute to the developing brain vasculature
2022 · Yuta Koui, Takako Ideue, et al. · Biology Open · 2
Leukopenia, macrocytosis, and thrombocytopenia occur in young adults with Down syndrome
2022 · Yo Hamaguchi, Tatsuro Kondoh, et al. · Gene · 7
Year
Topic