Get started
Award

91816631/528

Funded outputs count: 31
Funder award ID: 91816631/528
OpenAlex ID: G673075925
Development of Reliable and High‐Throughput Human Biomimetic Cartilage and Bone Models to Explore Senescence and Personalized Osteoarthritis Treatment Options
2025 · Ilja Boone, Evelyn Houtman, et al. · Journal of Orthopaedic Research® · 8
PDF
Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants
2025 · Margo Tuerlings, Evelyn Houtman, et al. · Arthritis Research & Therapy · 1
PDF
The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality
2024 · Ghazaleh Hajmousa, Rodrigo Coutinho de Almeida, et al. · Clinical Epigenetics · 10
PDF
A Damaging COL6A3 Variant Alters the MIR31HG ‐Regulated Response of Chondrocytes in Neocartilage Organoids to Hyperphysiologic Mechanical Loading
2024 · Niek GC Bloks, Zainab Harissa, et al. · Advanced Science · 18
Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids
2024 · Niek G. C. Bloks, Amanda Dicks, et al. · Clinical Epigenetics · 3
PDF
A high-impact COL6A3 mutation alters the response of chondrocytes in neo-cartilage organoids to hyper-physiologic mechanical loading
2022 · Niek GC Bloks, Zainab Harissa, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
PDF
WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes
2022 · M. Tuerlings, G.M.C. Janssen, et al. · Osteoarthritis and Cartilage · 13
PDF
Identification and functional characterization of imbalanced osteoarthritis-associated fibronectin splice variants
2022 · Marcella van Hoolwerff, Margo Tuerlings, et al. · Lara D. Veeken · 15
PDF
Mutation in the CCAL1 locus accounts for bidirectional process of human subchondral bone turnover and cartilage mineralization
2022 · Alejandro Rodríguez Ruiz, Marcella van Hoolwerff, et al. · Lara D. Veeken · 21
PDF
Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit‐on‐a‐Chip Model
2022 · Margo Tuerlings, Ilja Boone, et al. · Advanced Materials Technologies · 28
PDF
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
2022 · Evelyn Houtman, Margo Tuerlings, et al. · Lara D. Veeken · 7
PDF
WWP2 osteoarthritis risk allele rs1052429-A confers risk by affecting cartilage matrix deposition via hypoxia associated genes
2022 · Margo Tuerlings, George M.C. Janssen, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
PDF
ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease
2022 · S. Monteagudo, F.M.F. Cornelis, et al. · Osteoarthritis and Cartilage · 15
PDF
A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis
2022 · Georgia Katsoula, Julia Steinberg, et al. · Human Molecular Genetics · 30
PDF
High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II
2021 · Marcella van Hoolwerff, Alejandro Rodríguez Ruiz, et al. · Science Advances · 40
PDF
Long non-coding RNA expression profiling of subchondral bone reveals AC005165.1 modifying FRZB expression during osteoarthritis
2021 · Margo Tuerlings, Marcella van Hoolwerff, et al. · Lara D. Veeken · 18
PDF
Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility—Towards Identification of Applicable Early OA Biomarkers
2021 · Yolande F. M. Ramos, Rodrigo Coutinho de Almeida, et al. · Biomolecules · 7
PDF
Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants
2021 · Evelyn Houtman, Margo Tuerlings, et al. · Arthritis Research & Therapy · 33
PDF
Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells
2021 · Alejandro Rodríguez Ruiz, Amanda Dicks, et al. · Cell and Tissue Research · 41
PDF
The role of TNFRSF11B in development of osteoarthritic cartilage
2021 · Alejandro Rodríguez Ruiz, Margo Tuerlings, et al. · Lara D. Veeken · 27
PDF
Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin
2021 · E. Houtman, R. Coutinho de Almeida, et al. · Osteoarthritis and Cartilage · 17
PDF
Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis
2021 · Evelyn Houtman, Marcella van Hoolwerff, et al. · Rheumatology and Therapy · 24
PDF
RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets
2020 · Margo Tuerlings, Marcella van Hoolwerff, et al. · Arthritis & Rheumatology · 61
PDF
Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI
2020 · J. M. T. A. Meessen, F. Saberi-Hosnijeh, et al. · Scientific Reports · 13
PDF
Metabolic Age Based on the BBMRI-NL 1 H-NMR Metabolomics Repository as Biomarker of Age-related Disease
2020 · E.B. van den Akker, S. Trompet, et al. · Circulation Genomic and Precision Medicine · 108
PDF
Year
Topic