PNPase inhibition as an effective treatment for chronic bladder pain
Description: Narrative (Relevance) Chronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are among the most difficult types of pain to treat, and response to treatment is often negligible. Because there are no effective treatments that have shown significant clinical efficacy, our research program is dedicated to the validation of a non-opioid-based target, namely purine nucleoside phosphorylase (PNPase), and applying that knowledge to design and fast-track innovative therapies. Our expertise makes our research group uniquely suited to validate this non-opioid target for the treatment of IC/BPS.
Funder: National Institutes of Health
Amount: $2,371,000
Funding type: research
Funder scheme: R01
Start date: 2022-09-24
End date: 2025-08-31
Investigator: LORI A BIRDER
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 11
Funder award ID: 1r01dk135076-01
OpenAlex ID: G6740138592