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Neuronal FGF21 Signaling in the Detection of Dietary Protein Restriction

Description: PROJECT NARRATIVE The central nervous system is well documented to contribute to whole body energy and glucose metabolism. Furthermore, diet interventions such as protein restriction are reported to increase hormones, including FGF21, to maintain whole body homeostasis. This project will focus the specific role of CNS FGF21 signaling in the detection of protein restriction and resulting changes in energy expenditure and glucose metabolism.  
Funding type: fellowship
Funder scheme: F32
Start date: 2017-08-01
End date: 2020-07-31
Investigator: CRISTAL MONIQUE HILL
Institution: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
Funded outputs count: 11
Funder award ID: F32DK115137
OpenAlex ID: G6758446955
Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK ‐ ULK1 ‐Mediated Mitochondrial Quality Control
2026 · Wagner S. Dantas, Elizabeth R. M. Zunica, et al. · Aging Cell · 4
FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice
2022 · Cristal M. Hill, Diana C. Albarado, et al. · Nature Communications · 117
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Antiaging diets: Separating fact from fiction
2021 · Mitchell B. Lee, Cristal M. Hill, et al. · Science · 143
Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49th Annual Meeting of the American Aging Association
2021 · Michaela E. Murphy, Akilavalli Narasimhan, et al. · GeroScience · 4
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FGF21 prevents low-protein diet-induced renal inflammation in aged mice
2021 · Han Fang, Sujoy Ghosh, et al. · American Journal of Physiology-Renal Physiology · 20
The importance of diversity and outreach in geroscience research: Insights from the Annual Biomedical Research Conference for Minority Students
2020 · Mitchell B. Lee, Dibyadeep Datta, et al. · GeroScience · 4
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FGF21 and the Physiological Regulation of Macronutrient Preference
2020 · Cristal M Hill, Emily Qualls-Creekmore, et al. · Endocrinology · 99
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FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
2019 · Cristal M. Hill, Thomas Laeger, et al. · Cell Reports · 229
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Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice
2019 · Camille Allard, Fabrice Bonnet, et al. · Molecular Metabolism · 58
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Homeostatic sensing of dietary protein restriction: A case for FGF21
2018 · Cristal M. Hill, Hans-Rudolf Berthoud, et al. · Frontiers in Neuroendocrinology · 68
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Dietary branched chain amino acids and metabolic health: when less is more
2018 · Cristal M. Hill, Christopher D. Morrison · The Journal of Physiology · 12
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