The role of Abca1 in regulation of glial lipid metabolism in ApoE4-induced tauopathy and Alzheimer`s disease
Description: ApoE4 is the strongest genetic risk factor for developing late-onset AD and was shown to markedly elevate tau pathology and neurodegeneration in the P301S/ApoE4 tauopathy mice. A disruption of lipid metabolism in glia is linked to neuroinflammation and neurodegeneration in several studies; we recently detected a significant buildup of lipids in glia of aged P301S/ApoE4 animals. In this study, we will assess the role of Abca1 lipid transporter in modulation of glial lipid metabolism in the P301S/ApoE4 mice, thus, providing novel therapeutic avenues for treating tauopathy and AD.
Funder: BrightFocus Foundation
Amount: $200,000
Funding type: fellowship
Funder scheme: Alzheimer's Disease Research: Postdoctoral Fellowship
Start date: 2022-07-01
End date: 2024-06-30
Investigators: Alexandra Litvinchuk, Alexandra Litvinchuk
Institution: Washington University in St. Louis
Funded outputs count: 3
Funder award ID: A2022010F
OpenAlex ID: G6771326526