Mechanisms of aging in the tissue progenitor cells and tissue regeneration
Description: Telomeres are regions with tandem repeats of nucleotide sequences (TTAGGG) at each end of a chromatid in eukaryotes, and plays a key role in preventing chromosomal instability. In this study, we analyzed telomere length in exocrine cells of the human pancreas with and without cancer. The telomere length was the longest in ducts, followed by centroacinar cells, and acinar cells. Telomere length in duct, centroacinar and acinar cells decreased with age. The rate of decline in telomere length due to age was greater in duct cells, followed by centroacinar cells, and acinar cells. The length of telomeres in the duct and centroacinar cells of pancreatic cancer cases was shorter than that in the cells of the cases without cancers. In conclusion, critical telomere dysfunction in the centroacinar-acinar region is possibly due to high annual telomere attrition, which leads to chromosomal instability and carcinogenesis in the pancreas.
Amount: ¥4,680,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2016-07-19
End date: 2019-03-31
Investigator: Yoko Matsuda
Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Funded outputs count: 10
Funder award ID: 16KT0125
OpenAlex ID: G6791148986