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Exploring the role of fibulin 7 as an anti-inflammatory ECM in psoriasis

Description: To elucidate the function of Fbln7 in mouse psoriasis model and its mechanism by phosphoproteomics, identification of its receptor, upstream regulators during inflammation and if fibulin 7 binding to the basement membrane reduces T-cell activation in the epidermis.
Amount: ¥4,550,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2023-04-01
End date: 2026-03-31
Investigator: Erna Raja
Institution: University of Tsukuba
Subfield: Genetics
Funded outputs count: 3
Funder award ID: 23K07737
OpenAlex ID: G67969538
The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis model
2026 · Erna Raja, Tomoko Machida, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Fibrillin-1 G234D mutation in the hybrid1 domain causes tight skin associated with dysregulated elastogenesis and increased collagen cross-linking in mice
2024 · ASM Sakhawat Hossain, Maria Thea Rane Dela Cruz Clarin, et al. · Matrix Biology · 4
Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
2023 · Erna Raja, Maria Thea Rane Dela Cruz Clarin, et al. · International Journal of Molecular Sciences · 34
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