A novel model for causing senescence via mitochondrial dysfunction by environmental factors
Description: Mitochondria are dynamic organella that can change its structure and morphology by repeating fission and fussion cycle, and its quality control is essential for maintenance of body health. In this study, we aimed to reveal the influence of environmental factors on mitochondrial quality and early senescence in view of redox signaling, and identify a novel anti-aging drug. We found that dynamin-related protein 1 (Drp1), a mitochondrial fission-promoting protein, forms polysulfide (Cys-SSH) in protein and depolysulfidation of Drp1 by environmental electrophiles triggered Drp1 activation, which led to mitochondrial fission-mediated myocardial early senescence, resulting in causing cardiac vulnerability against hemodynamic load in mice.
Amount: ¥18,460,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-07-19
End date: 2019-03-31
Investigator: Motohiro Nishida
Institution: Center for Novel Science Initatives, National Institutes of Natural Sciences(2018)Okazaki Research Facilities, National Institutes of Natural Sciences(2016-2017)
Funded outputs count: 19
Funder award ID: 16KT0013
OpenAlex ID: G6797925330