Regulatory mechanisms of vitamin K metabolism through GTP metabolic sensors and their application to cancer therapy.
Description: Vitamin K has been reported to have two functions: anti-tumour and prevention of cancer recurrence, but the mechanisms of these effects are not clear. We have previously found that the vitamin K-converting enzyme UBIAD1 is regulated by GTP energy metabolism. This study aimed to "Regulatory mechanisms of vitamin K metabolism through GTP metabolic sensors and their application to cancer therapy." I came to the USA at the time of the COVID-19 outbreak worldwide, so the research plan was modified to generate F205L knock-in mice by genome editing of the GTP sensor gene and analysing the phenotype. The GTP sensor was found to affect body weight change, glucose metabolism and life span in the mice.
Amount: ¥15,600,000
Funding type: research
Funder scheme: Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
Investigator: Yoshihisa Hirota
Institution: Shibaura Institute of Technology
Funded outputs count: 14
Funder award ID: 18KK0455
OpenAlex ID: G6806506423