Get started
Award

Significance of APE1 as a Diagnostic and Therapeutic Target Molecule in Onco-Cardiology

Description: There have been no biomarkers and no curative measures for doxorubicin (DOX) cardiotoxicities. We proposed APE1 as a potential target molecule to solve this issue. APE1 is multifunctional, with repairing DNA damage and antioxidative functions. A DOX mouse model demonstrated an enhanced APE1 expression, parallel with progression of cardiac dysfunction dose-dependently to DOX, suggesting a possible role of APE1 as a significant biomarker of DOX cardiotoxicity. APE1 gene transfection reduced myocardial damage in DOX cardiotoxicity model. Advanced experiments on dose-dependency of cardioprotective effects of APE1 has been progressing.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Naoyuki Hasebe
Institution: Asahikawa Medical College
Field: Medicine
Funded outputs count: 26
Funder award ID: 18K08093
OpenAlex ID: G6820248602
Characteristics of Neurological Symptoms in Adult Japanese Patients with Fabry Disease
2021 · Jun Sawada, Naoki Nakagawa, et al. · Internal Medicine · 14
PDF
Imaging and Pathological Evaluation of Deep Intramural Ventricular Tachycardia After Combined Bipolar and Ethanol Ablation
2020 · Naka Sakamoto, Yuki Komatsu, et al. · JACC. Clinical electrophysiology
High prevalence of masked uncontrolled morning hypertension in elderly non‐valvular atrial fibrillation patients: Home blood pressure substudy of the ANAFIE Registry
2020 · Kazuomi Kario, Naoyuki Hasebe, et al. · Journal of Clinical Hypertension · 12
PDF
Potential common pathophysiological pathway of hypertension-mediated organ damage in hypertensive emergency
2020 · Naoki Nakagawa, Naoyuki Hasebe · Hypertension Research · 1
PDF
Antimitochondrial Antibody-associated Myopathy with Slowly Progressive Cardiac Dysfunction
2020 · Fumihiko Takahashi, Jun Sawada, et al. · Internal Medicine · 10
PDF
Malignant hypertension and multiorgan damage: mechanisms to be elucidated and countermeasures
2020 · Tsukasa Saito, Naoyuki Hasebe · Hypertension Research · 9
PDF
Acute Myocardial Infarction in a 17-year-old High-school Girl
2020 · Satoshi Kawaguchi, Tomomi Hasebe, et al. · Internal Medicine · 5
PDF
Assessment of suitable antihypertensive therapies: Combination with high‐dose amlodipine/irbesartan vs triple combination with amlodipine/irbesartan/indapamide (ASAHI‐AI study)
2020 · Naoki Nakagawa, Nobuyuki Sato, et al. · Journal of Clinical Hypertension · 5
EphA7+ perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model
2020 · Kohei Kano, Kiwamu Horiuchi, et al. · Stem Cell Research · 12
PDF
Japanese Heart Failure Society 2018 Scientific Statement on Nutritional Assessment and Management in Heart Failure Patients
2020 · Kazuhiro Yamamoto, Miyuki Tsuchihashi-Makaya, et al. · Circulation Journal · 37
PDF
Physician and patient perspectives on hypertension management and factors associated with lifestyle modifications in Japan: results from an online survey
2020 · Nobuhiro Nishigaki, Yukio Shimasaki, et al. · Hypertension Research · 31
PDF
Perspectives of patients and physicians regarding hypertensive management from an online survey for excellence: a subanalysis of the PARADOX study by physician categories
2020 · Takuo Yoshida, Nobuhiro Nishigaki, et al. · Hypertension Research · 13
PDF
β3-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism
2019 · Satoshi Kawaguchi, Motoi Okada, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 31
PDF
Cerebrospinal fluid levels of alpha-synuclein, amyloid β, tau, phosphorylated tau, and neuron-specific enolase in patients with Parkinson’s disease, dementia with Lewy bodies or other neurological disorders: Their relationships with cognition and nuclear medicine imaging findings
2019 · Takayuki Katayama, Jun Sawada, et al. · Neuroscience Letters · 16
The First Case of Spinocerebellar Ataxia Type 8 in Monozygotic Twins
2019 · Jun Sawada, Takayuki Katayama, et al. · Internal Medicine · 4
PDF
Comparison of blood pressure values—self-measured at home, measured at an unattended office, and measured at a conventional attended office
2019 · The Japanese Society of Hypertension Working Group on the COmparison of Self-measured home, Automated unattended office and Conventional attended office blood pressure (COSAC) study, Kei Asayama, et al. · Hypertension Research · 32
PDF
High-risk screening for Anderson–Fabry disease in patients with cardiac, renal, or neurological manifestations
2019 · Naoki Nakagawa, Jun Sawada, et al. · Journal of Human Genetics · 22
The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system
2019 · Keisuke Maruyama, Naoki Nakagawa, et al. · Scientific Reports · 7
PDF
JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension–the JSH Asahikawa declaration
2019 · Satoko Nakamura, Naoyuki Hasebe, et al. · Hypertension Research · 2
PDF
Diffuse Alveolar Hemorrhaging with Hypertensive Emergency: A Rare but Important Cause of Hemoptysis
2019 · Ayana Suzuki, Naoki Nakagawa, et al. · Internal Medicine · 10
PDF
JSH Statement: Kyoto declaration on hypertension research in Asia
2019 · Masaaki Ito, Toshihiko Ishimitsu, et al. · Hypertension Research · 6
PDF
Impact of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia
2019 · Naoki Nakagawa, Naoyuki Hasebe · Current Hypertension Reports · 24
Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease
2018 · Yuya Kitani, Naoki Nakagawa, et al. · Circulation Journal · 21
PDF
Case of Invasive Streptococcus Dysgalactiae Infection Presenting as Infective Endocarditis with Multiple Brain Embolisms
2018 · Fumihiko Takahashi, Yoshiki Wada, et al. · International Heart Journal · 4
PDF
Efficacy of Endocardial Ablation of Drug-Resistant Ventricular Fibrillation in Brugada Syndrome
2018 · Ahmed Karim Talib, Masahiko Takagi, et al. · Circulation Arrhythmia and Electrophysiology · 34
Year
Topic