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Regulation of myocardial growth and death by autophagy

Description: Autophagy, an important mechanism of protein degradation through lysosomes, plays an adaptive role in various pathophysiological conditions. Our study will elucidate the role of autophagy in mediating both physiological and pathological functions under stresses and underlying signaling mechanisms regulating autophagy in the heart. The knowledge obtained from this study may lead to better understanding of the mechanism of myocardial injury and heart failure and the development of novel strategies to treat patients with myocardial infarction and cardiomyopathy.
Funding type: research
Funder scheme: R01
Start date: 2010-04-15
End date: 2016-03-31
Investigator: JUNICHI SADOSHIMA
Institution: RBHS-NEW JERSEY MEDICAL SCHOOL
Subfield: Epidemiology
Field: Medicine
Funded outputs count: 145
Funder award ID: R01HL102738
OpenAlex ID: G4046088456
PPARα–NF-κB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6
2026 · Shin-ichi Oka, Eun-Ah Sung, et al. · Journal of Clinical Investigation · 5
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Microtubule affinity-regulating kinase 4 exacerbates diabetic cardiomyopathy by inhibiting UNC-51-like kinase 1-mediated mitochondrial autophagy
2026 · Yi Wu, Wei-Yi Wang, et al. · World Journal of Diabetes · 1
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Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell-protective mechanisms in cardiomyocytes
2024 · Yasuhiro Maejima, Jihoon Nah, et al. · Nature Communications · 21
Regulation of myocardial glucose metabolism by YAP/TAZ signaling
2024 · Toshihide Kashihara, Junichi Sadoshima · Journal of Cardiology · 7
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Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes
2023 · Yuka Shiheido-Watanabe, Junichi Sadoshima · The Journal of Cardiovascular Aging · 1
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Mitophagy for cardioprotection
2023 · Allen Sam Titus, Eun-Ah Sung, et al. · Basic Research in Cardiology · 119
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Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice
2023 · Michinari Nakamura, Mariko Aoyagi Keller, et al. · Nature Communications · 11
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Ketone Bodies Preserve Mitochondria Through Epigenetics
2023 · Risa Mukai, Junichi Sadoshima · JACC Basic to Translational Science · 3
Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy
2023 · Mingming Tong, Risa Mukai, et al. · Circulation Research · 92
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Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts
2023 · Junichi Sadoshima · Circulation · 1
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Molecular properties and regulation of NAD+ kinase (NADK)
2022 · Shin-ichi Oka, Allen Sam Titus, et al. · Redox Biology · 76
PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α
2022 · Chun-yang Huang, Shin-ichi Oka, et al. · Scientific Reports · 18
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Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion
2022 · Shouji Matsushima, Junichi Sadoshima · Antioxidants · 47
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TRAF2 Mediates Physiological Mitophagy
2022 · Junichi Sadoshima · JACC Basic to Translational Science · 3
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The role of the Hippo pathway in autophagy in the heart
2022 · Yasuhiro Maejima, Daniela Zablocki, et al. · Cardiovascular Research · 44
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Alternative mitophagy is a major form of mitophagy in the chronically stressed heart
2022 · Junichi Sadoshima · Autophagy · 9
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Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of β- hydroxybutyrate: implications in cardioprotection and aging
2022 · Junichi Sadoshima Sadoshima · The Journal of Cardiovascular Aging
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Myocardin-related transcription factor A in macrophages mediates pathological hypertrophy
2021 · Junichi Sadoshima · Cardiovascular Research · 3
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Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy?
2021 · Sebastiano Sciarretta, Maurizio Forte, et al. · The Journal of Cardiovascular Aging · 3
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The role of autophagy in death of cardiomyocytes
2021 · Shohei Ikeda, Daniela Zablocki, et al. · Journal of Molecular and Cellular Cardiology · 100
Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload
2021 · Dan Shao, Peiyong Zhai, et al. · Scientific Reports · 16
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Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy
2021 · Shin-ichi Oka, Jaemin Byun, et al. · Circulation Research · 59
The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death
2021 · Jihoon Nah, Daniela Zablocki, et al. · Experimental & Molecular Medicine · 25
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A Novel Inducer of Autophagy in the Heart
2021 · Risa Mukai, Junichi Sadoshima · JACC Basic to Translational Science · 2
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Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy
2021 · Yanbin Chen, Yasuhiro Maejima, et al. · The Journal of Cardiovascular Aging · 10
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