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Cape Town Adolescent Antiretroviral Cohort (CTAAC)

Description: As older children infected with HIV survive longer with antiretroviral therapy (ART) across Africa and Asia, they are likely to experience more effects from chronic HIV disease and ART use. However little is known about the development of chronic diseases in these children, particularly involving the heart and circulatory system, the lungs, and the brain. This information is important in understanding how HIV/AIDS influences other diseases in children and adolescents, and in turn, how best to improve the health of HIV infected children over time.
Funding type: research
Funder scheme: R01
Start date: 2012-09-01
End date: 2018-12-31
Investigator: HEATHER JOY ZAR
Institution: UNIVERSITY OF CAPE TOWN
Field: Medicine
Funded outputs count: 52
Funder award ID: R01HD074051
OpenAlex ID: G8589528972
Metabolic syndrome and Pathobiological Determination of Atherosclerosis in Youth risk score in adolescents with and without perinatally acquired HIV in the Cape Town Adolescent and Antiretroviral Cohort ( CTAAC )‐Heart study
2025 · Sahera Dirajlal‐Fargo, Mothabisi Nyathi, et al. · HIV Medicine · 3
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Cardiometabolic Biomarkers and Systemic Inflammation in US Adolescents and Young Adults With Latent Tuberculosis Infection: A Population-Based Cohort Study
2025 · Itai M Magodoro, Ntobeko A B Ntusi, et al. · Open Forum Infectious Diseases · 2
Are children and adolescents living with HIV in Europe and South Africa at higher risk of SARS-CoV-2 and poor COVID-19 outcomes?
2025 · The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) SARS-CoV-2 Antibody Study Group · Epidemiology and Infection · 1
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Association of prior tuberculosis with cardiovascular status in perinatally HIV-1-infected adolescents
2024 · Itai M Magodoro, Carlos Eduardo Guerrero-Chalela, et al. · Open Heart
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Subclinical Myocardial Fibrosis in South African Youth With HIV: Results From the CTAAC-Heart Study
2024 · Jennifer Jao, Heather J Zar, et al. · Open Forum Infectious Diseases · 6
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Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection
2024 · Itai M. Magodoro, Carlos E. Guerrero-Chalela, et al. · Scientific Reports · 3
Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder
2024 · Natalie C.W. Ho, Richard A.I. Bethlehem, et al. · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · 5
Effect of prior tuberculosis on cardiovascular status in perinatally HIV-1-infected adolescents
2024 · Itai M Magodoro, Carlos E Guerrero-Chalela, et al. · medRxiv
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The Determinants of Elevated Pathobiological Determination of Atherosclerosis in Youth Risk Score in Perinatally HIV-Infected Adolescents in South Africa
2023 · Sana Mahtab, Lisa J. Frigati, et al. · JAIDS Journal of Acquired Immune Deficiency Syndromes · 7
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Left ventricular remodeling and its correlates among adolescents with perinatally acquired HIV in South Africa
2023 · Itai M. Magodoro, Carlos E. Guerrero-Chalela, et al. · International Journal of Cardiology · 13
Persistent accelerated epigenetic ageing in a longitudinal cohort of vertically infected HIV-positive adolescents
2023 · Sarah J. Heany, Andrew J. Levine, et al. · Journal of NeuroVirology · 8
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Normal values of respiratory oscillometry in South African children and adolescents
2023 · Shaakira Chaya, Rae MacGinty, et al. · ERJ Open Research · 12
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Genetic variants associated with longitudinal changes in brain structure across the lifespan
2022 · Rachel M. Brouwer, Marieke Klein, et al. · Nature Neuroscience · 229
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Physical development and mental health in South African perinatally HIV-positive adolescents on antiretroviral therapy and their caregivers with and without household food insecurity
2021 · Sarah Heany, Nicole Phillips, et al. · Southern African Journal of HIV Medicine
Alcohol use is associated with mental health problems and brain structural alterations in adolescents with perinatally acquired HIV infection on ART
2021 · Jacqueline Hoare, Jean-Paul Fouche, et al. · Alcohol · 7
HIV-Related Stigma and Psychological Adjustment Among Perinatally HIV-Infected Youth in Cape Town, South Africa
2021 · Alexander Perez, Kirsty Brittain, et al. · AIDS and Behavior · 14
The association between mental health and metabolic outcomes in youth living with perinatally acquired HIV in the Cape Town Adolescent Antiretroviral Cohort
2021 · Sana Mahtab, Jennifer Jao, et al. · AIDS Care · 4
Childhood Trauma and Mental Health in the Cape Town Adolescent Antiretroviral Cohort
2021 · Tatum Sevenoaks, Jean-Paul Fouche, et al. · Journal of Child & Adolescent Trauma · 13
Tuberculosis infection and disease in South African adolescents with perinatally acquired HIV on antiretroviral therapy: a cohort study
2021 · Lisa J Frigati, Katalin A Wilkinson, et al. · Journal of the International AIDS Society · 20
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Youth perinatal HIV-associated neurocognitive disorders: association with functional impairment
2021 · Nicole Phillips, Kevin G. F. Thomas, et al. · AIDS Care · 10
Accelerated epigenetic aging in adolescents living with HIV is associated with altered development of brain structures
2021 · Jacqueline Hoare, Dan J. Stein, et al. · Journal of NeuroVirology · 22
Hospitalization in South African Adolescents With Perinatally Acquired HIV on Antiretroviral Therapy
2020 · Lisa J. Frigati, Karryn Brown, et al. · The Pediatric Infectious Disease Journal · 6
Prevalence and predictors of bone health among perinatally HIV-infected adolescents
2020 · Sana Mahtab, Chris Scott, et al. · AIDS · 7
Monocyte activation and gut barrier dysfunction in South African youth on antiretroviral therapy and their associations with endothelial dysfunction
2020 · Sahera Dirajlal-Fargo, Jiao Yu, et al. · AIDS · 16
Accelerated epigenetic aging in adolescents from low-income households is associated with altered development of brain structures
2020 · Jacqueline Hoare, Dan J. Stein, et al. · Metabolic Brain Disease · 25
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