Therapeutic strategy for diabetic microcirculatory disorder using transcutaneous carbon dioxide absorption combined pulsed ultrasonic irradiation
Description: Chronic hyperglycemia exposure caused a decrease in citrate synthase activity and regression of capillary network in skeletal muscle. Carbon absorption suppressed the decline of citrate synthase activity and capillary regression due to hyperglycemia and suppressed blood glucose rise. Furthermore, the expression levels of eNOS, PGC-1α, COX IV, and VEGF proteins related to metabolism and angiogenesis were increased and the expression level of angiogenesis inhibitor (TSP-1) was decreased in skeletal muscle. Pulsed ultrasound irradiation increased phosphorylation of integrin/focal adhesion kinase (FAK) and decrease phosphorylation of p38MAPK in myotubes induced inflammation. The irradiation also reduced the expression of inflammatory cytokines. These results indicated that percutaneous absorption of carbon dioxide and pulsed ultrasound therapy could be an effective intervention against microangiopathy induced by diabetes.
Amount: ¥17,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2016-04-01
End date: 2019-03-31
Investigator: Hiroyo Kondo
Institution: Nagoya Women's University
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Funded outputs count: 13
Funder award ID: 16H03208
OpenAlex ID: G68637212