Membrane lipid peroxidation is involved in the pathogenesis of Parkinson disease
Description: RRecently, the production and the occurrence of abnormal alpha-synuclein (aS) protein is suggested to play a central role in the neurodegeneration in Parkinson disease (PD). aS is known to occur in the neurons interacting with membrane lipid bilayer, but its function is not clear. In human neuroblastoma SH-SY5Y cells overexpressing aS, lysosome activity was found to be reduced and macroautophagy activity was compensatory increased. aS overexpression protected cells from oxidative stress by membrane-composing docosahexaenoic acid (DHA) and aggregated aS was found to be modified by lipid hydroperoxide derived from DHA. aS may function as a scavenger of lipid radicals by adduct formation and as a result, toxic modified aS is continuously produced in the neurons. Decreased activity of macroautophagy in ageing and PD may be responsible for neuronal death by reduced degradation of toxic aS oligomer modified by lipid radicals.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Wakako Maruyama
Institution: Aichi Gakuin University
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 4
Funder award ID: 18K07430
OpenAlex ID: G6894415318