Uncovering the hypoxia-metabolic axis regulating heart regeneration
Description: Cardiovascular diseases are the leading cause of death in industrialized countries. Cardiac diseases are characterized by cardiomyocyte deficiency and impaired heart function that ultimately leads to congestive heart failure. Conventional treatments do not correct the defects in cardiomyocyte numbers and the prognosis of congestive heart failure remains poor. Specific needs remain for new strategies to enhance cardiac regeneration and to replace cardiomyocytes following injury. Nowadays, the stimulation of terminally differentiated cardiomyocyte proliferation represents the main therapeutic approach for heart regeneration. We recently uncovered that the modulation of the hypoxic and metabolic status of adult cardiomyocytes promotes heart regeneration. The MetabOx-Heart project aims to decipher the interplay between hypoxic and metabolic signaling to induce heart regeneration. This will lead to original and innovative concepts contributing to advances in heart repair and regeneration.
Funder: Agence Nationale de la Recherche
Amount: €505,500
Funding type: research
Funder scheme: AAPG2020
Start date: 2021-03-01
Investigator: Francesca ROCHAIS
Institution: Centre de Génétique Médicale de Marseille (Marseille Medical Genetics)
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 6
Funder award ID: ANR-20-CE14-0003
OpenAlex ID: G6898517840