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NOTCH3 N-terminal fragmentation in cerebral small vessel disease

Description: NARRATIVE Though small vessel disease (SVD) of the brain has been well-described as a cause of stroke and vascular dementia, little is known about its molecular pathogenesis. We have discovered a new protein fragment of NOTCH3 (NTF), derived from the N-terminus of the protein. Identification of a role for NTF in SVD pathogenesis could provide a new therapeutic target for treatment of SVD.

Funder: National Institute of Neurological Disorders and Stroke

Funding type: research

Funder scheme: R01

Start date: 2018-08-01

End date: 2024-04-30

Investigator: MICHAEL M WANG

Institution: UNIVERSITY OF MICHIGAN AT ANN ARBOR

Topic: Cerebrovascular and genetic disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 21

Funder award ID: R01NS099160

OpenAlex ID: G4888746901