Genome-wide association studies (GWAS) of quantitative traits with repeated measures related to the process of aging
Description: The Canadian Longitudinal Study on Aging (CLSA) is designed to provide an accurate picture of the dynamic process of adult development and healthy aging. It has collected detailed measures of various aspects of aging in the study participants at baseline and, to date, at one or two followup visits. These include physical measurements of strength and mobility, cognitive metadata and scores, measures of bone density, frailty indices and scores, and biological markers from blood chemistry associated with mechanisms of aging and/or diseases of aging. The aim of this project is to conduct data analyses that combine repeated measures with individuals' genetic information in order to better understand the role of genetic variation involved in the process of aging. The analyses aim to identify genetic variation and regions of the genome that are (1) associated with differences between individuals in their measures at a single point point, and/or (2) associated with changes within an individual over time. This knowledge could improve future investigations that study environmental and sociodemographic together with genetic factors, and ultimately lead to new population or therapeutic interventions.
Amount: CA$69,960
Funding type: research
Funder scheme: Catalyst Grant: Analysis of CLSA Data - Brain Health and Cognitive Impairment in Aging
Start date: 2025-03-01
End date: 2026-02-28
Investigator: Shelley Bull
Institution: Lunenfeld-Tanenbaum Research Institute (Toronto)
Subfield: Genetics
Domain: Life Sciences
Funded outputs count: 0
Funder award ID: 200190_1
OpenAlex ID: G6933650317